Triumbelletin CAS NO.131559-54-1

Min.Order: 10 Milligram
Payment Terms: T/T
Available Specifications:

Product Details

Keywords

Triumbelletin
131559-54-1
standard supplier in China

Quick Details

ProName: Triumbelletin
CasNo: 131559-54-1
Molecular Formula: C27H14O9
Appearance: detailed see specifications
Application: analysis,activity test,Botanical Refer...
DeliveryTime: 1-3?working?days?after?confirming?the?...
PackAge: According to the clients requirement.
Port: China main port
ProductionCapacity: 1 Metric Ton/Day
Purity: 98%
Storage: Store at 2~8°C
Transportation: by air or by ocean shipping
LimitNum: 10 Milligram
Plant of Origin: Chinese herbal medicine
Testing Method: NMR/MS/HPLC
Product Ecification: 1mg-1kg
Heavy Metal: <10ppm
Voluntary Standards: company standard
Storage: Brown vial HDPE plastic bottle

Superiority

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.

Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library

1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries

General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Details

Chemical Properties of Triumbelletin

Cas No.	131559-54-1	SDF
PubChem ID	14213530	Appearance	Powder
Formula	C₂₇H₁₄O₉	M.Wt	482.39
Type of Compound	Coumarins	Storage	Desiccate at -20°C
Solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name	7-hydroxy-8-(7-hydroxy-2-oxochromen-8-yl)-3-(2-oxochromen-7-yl)oxychromen-2-one
SMILES	C1=CC(=CC2=C1C=CC(=O)O2)OC3=CC4=C(C(=C(C=C4)O)C5=C(C=CC6=C5OC(=O)C=C6)O)OC3=O
Standard InChIKey	GDHDMCIEKMVPIP-UHFFFAOYSA-N
Standard InChI	InChI=1S/C27H14O9/c28-17-7-2-14-5-10-22(31)35-25(14)23(17)24-18(29)8-3-15-11-20(27(32)36-26(15)24)33-16-6-1-13-4-9-21(30)34-19(13)12-16/h1-12,28-29H
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Triumbelletin

The herbs of Wikstroemia indica

Biological Activity of Triumbelletin

Description

Triumbelletin is a natural product from Wikstroemia indica.

In vitro

Phenolic Constituents from Rhizome of Wikstroemia indica and Their Anti-tumor Activity[Reference: WebLink]

Natural Product Research & Development, 2014 , 26 (6) :851-5.

METHODS AND RESULTS:
Seventeen phenolic constituents were isolated from the rhizome of Wikstroemia indica using a combination of various chromatographic methods. Their structures were elucidated and identified as wikstromol( 1),matairesinol( 2),syringaresinol( 3),pinoresinol( 4),isolariciresinol( 5),ciwujiatone( 6),isorhamnetin-3-O-robinobioside( 7),wikstaiwanone A( 8),wikstaiwanone B( 9),kaempferol( 10),rutin( 11),daphnoretin( 12),Triumbelletin( 13),alnusdiol( 14),aloe-emodin-8-O-β-D-glucoside( 15),chlorogenic acid( 16) and p-hydroxybenzoic acid( 17) by physicochemical properties and spectral data including NMR and MS. Compounds 3-9 and 13-16 were isolated from this plant for the first time.
CONCLUSIONS:
The anti-tumor tests showed compounds 1-4,6-9 exhibited different activities against colon cancer cell lines SW480 and SW620,in which compound 6 showed most significant activities against the two cell lines.

Protocol of Triumbelletin

Structure Identification

J Sep Sci. 2015 Jun;38(12):2093-100.

Ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry coupled with hierarchical cluster analysis to evaluate Wikstroemia indica (L.) C. A. Mey. from different geographical regions.[Pubmed: 25866087]

METHODS AND RESULTS:
A sensitive, rapid and simple ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry method was developed to determine seven constituents (umbelliferone, apigenin, Triumbelletin, daphnoretin, arctigenin, genkwanin and emodin) in Wikstroemia indica (L.) C. A. Mey. The chromatographic analysis was performed on an ACQUITY UPLC® BEH C18 column (2.1 × 50 mm, 1.7 μm) by gradient elution with the mobile phase of 0.05% formic acid aqueous solution (A) and acetonitrile (B).
CONCLUSIONS:
Multiple reaction monitoring mode with positive and negative electrospray ionization interface was carried out to detect the components. This method was validated in terms of specificity, linearity, accuracy, precision and stability.

Preparing Stock Solutions of Triumbelletin

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.073 mL	10.3651 mL	20.7301 mL	41.4602 mL	51.8253 mL
5 mM	0.4146 mL	2.073 mL	4.146 mL	8.292 mL	10.3651 mL
10 mM	0.2073 mL	1.0365 mL	2.073 mL	4.146 mL	5.1825 mL
50 mM	0.0415 mL	0.2073 mL	0.4146 mL	0.8292 mL	1.0365 mL
100 mM	0.0207 mL	0.1037 mL	0.2073 mL	0.4146 mL	0.5183 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.