Kaempferol 7-O-rhamnoside CAS NO.20196-89-8

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ProName: Kaempferol 7-O-rhamnoside
CasNo: 20196-89-8
Molecular Formula: C21H20O10=432.4
Appearance: detailed see specifications
Application: analysis,activity test,Botanical Refer...
DeliveryTime: 1-3?working?days?after?confirming?the?...
PackAge: According to the clients requirement.
Port: China main port
ProductionCapacity: 1 Metric Ton/Day
Purity: ≥98%
Storage: Store at 2~8°C
Transportation: by air or by ocean shipping
LimitNum: 10 Milligram
Plant of Origin: Chinese herbal medicine
Testing Method: NMR/MS/HPLC
Product Ecification: 1mg-1kg
Heavy Metal: <10ppm
Voluntary Standards: company standard
Storage: Store in dry, dark and ventilated plac...
PackAge: Brown vial HDPE plastic bottle

Superiority

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.

Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library

1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries

General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Details

Chemical Properties of Kaempferol 7-O-rhamnoside

Cas No.	20196-89-8	SDF
PubChem ID	25079965	Appearance	Yellow powder
Formula	C₂₁H₂₀O₁₀	M.Wt	432.4
Type of Compound	Flavonoids	Storage	Desiccate at -20°C
Solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name	3,5-dihydroxy-2-(4-hydroxyphenyl)-7-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one
SMILES	CC1C(C(C(C(O1)OC2=CC(=C3C(=C2)OC(=C(C3=O)O)C4=CC=C(C=C4)O)O)O)O)O
Standard InChIKey	HQNOUCSPWAGQND-GKLNBGJFSA-N
Standard InChI	InChI=1S/C21H20O10/c1-8-15(24)17(26)19(28)21(29-8)30-11-6-12(23)14-13(7-11)31-20(18(27)16(14)25)9-2-4-10(22)5-3-9/h2-8,15,17,19,21-24,26-28H,1H3/t8-,15-,17+,19+,21-/m0/s1
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Kaempferol 7-O-rhamnoside

The herbs of Maytenus hookeri

Biological Activity of Kaempferol 7-O-rhamnoside

Description

Kaempferol 7-O-rhamnoside is a natural product from Maytenus hookeri.

In vitro

Constituent analysis of the ethanol extracts of Chimonanthus nitens Oliv. leaves and their inhibitory effect on α-glucosidase activity.[Pubmed: 28223131]

International Journal of Biological Macromolecules, 2017,98:829-36.

The ethanol extracts of Chimonanthus nitens Oliv. leaves were prepared sequentially by ethanol gradient elution and tested for their α-glucosidase inhibitory.
METHODS AND RESULTS:
The fraction of 50% ethanol eluate (EE) exhibited the notable inhibition with IC50 of 0.376mg/mL. Also, 50% EE was chemically characterized by liquid chromatography-mass spectrometry (LC-MS) analysis. Eight compounds including rutin (1), hyperin (2), isoquercitrin (3), luteoloside (4), astragalin (6), quercetin (13), naringenin (14), kaempferol (15) were identified by compared with standard substances as well as proper luteolin-5-O-glucoside (5), Kaempferol 7-O-rhamnoside (9), 5,7,8-trihydroxy-2-methoxyl-flavone-7-O-glucoside (10), kaempferol-7-O-acetyl-galactoside (11). The experiments of ultra-filtration combined with liquid chromatography-mass spectrometry (UF-LC-MS) guided quercetin and kaempferol as the key factors for 50% EE showing highly inhibitory activity on α-glucosidase. Quercetin and kaempferol inhibited yeast α-glucosidase in a mixed-type manner with IC50 of 66.8 and 109μg/mL, respectively.
CONCLUSIONS:
These results would provide theoretical underpinning for the C. nitens Oliv. leaves ethanol extracts used as nutraceutical health supplement in the management of type 2 diabetes.

Flavonoids from the leaves of Physalis angulata Linn.[Reference: WebLink]

Planta Med 2013; 79 - PJ5

Plants from the genus Physalis are particularly rich in secondary metabolites. Physalis angulata is a widely distributed annual plant belonging to the nightshade family Solanaceae. Physalis angulata have been used for centuries as medicinal herbs in the treatment of urinary tract infection, skin diseases, gonnorhea, ulcers, sores and as vermicidal drug [1,2].
METHODS AND RESULTS:
The main purpose of this present study is to screen the leaves of this plant for phytochemical constituents that may be responsible for some of these biological activities. The dried leaves of Physalis angulata were sequentially extracted with dichloromethane and 70% methanol. The aqueous methanol extract was partitioned between ethyl acetate and n-butanol. From the n-butanol fraction, four Flavonoids were isolated through column chromatography over silica gel G and sephadex LH-20. Based on the spectroscopic data which include NMR and mass spectroscopy, the chemical structures were determined as quercetin (1), quercetin 3-O-methyl ether (2) isoquercetrin (3) and Kaempferol 7-O-rhamnoside (4).
CONCLUSIONS:
The structures were elucidated using spectroscopic technique and compared with literature [3 – 4]. Anti-oxidant activity using DPPH and anti-bacterial activity of the flavonoids were also investigated. These compounds were isolated for the first time from the leaves of this plant.

Preparing Stock Solutions of Kaempferol 7-O-rhamnoside

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3127 mL	11.5634 mL	23.1267 mL	46.2535 mL	57.8168 mL
5 mM	0.4625 mL	2.3127 mL	4.6253 mL	9.2507 mL	11.5634 mL
10 mM	0.2313 mL	1.1563 mL	2.3127 mL	4.6253 mL	5.7817 mL
50 mM	0.0463 mL	0.2313 mL	0.4625 mL	0.9251 mL	1.1563 mL
100 mM	0.0231 mL	0.1156 mL	0.2313 mL	0.4625 mL	0.5782 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.