ligustroflavone CAS NO.260413-62-5

Min.Order: 10 Milligram
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ProName: ligustroflavone
CasNo: 260413-62-5
Molecular Formula: C33H40O18=724.67
Appearance: detailed see specifications
Application: analysis,activity test,Botanical Refer...
DeliveryTime: 1-3?working?days?after?confirming?the?...
PackAge: According to the clients requirement.
Port: China main port
ProductionCapacity: 1 Metric Ton/Day
Purity: ≥98%
Storage: Store at 2~8°C
Transportation: by air or by ocean shipping
LimitNum: 10 Milligram
Plant of Origin: Chinese herbal medicine
Testing Method: NMR/MS/HPLC
Product Ecification: 1mg-1kg
Heavy Metal: <10ppm
Voluntary Standards: company standard
Storage: Store in dry, dark and ventilated plac...
PackAge: Brown vial HDPE plastic bottle

Superiority

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.

Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library

1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries

General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Details

Chemical Properties of Ligustroflavone

Cas No.	260413-62-5	SDF
PubChem ID	10417462	Appearance	White-yellowish powder
Formula	C₃₃H₄₀O₁₈	M.Wt	724.67
Type of Compound	Flavonoids	Storage	Desiccate at -20°C
Synonyms	Nuezhenoside
Solubility	DMSO : 250 mg/mL (344.99 mM; Need ultrasonic)
Chemical Name	7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)chromen-4-one
SMILES	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC=C(C=C5)O)O)OC6C(C(C(C(O6)C)O)O)O)O)O)O)O)O
Standard InChIKey	NULBHTHMVOCGOE-ZBCCAYPVSA-N
Standard InChI	InChI=1S/C33H40O18/c1-11-22(37)25(40)28(43)31(46-11)45-10-20-24(39)27(42)30(51-32-29(44)26(41)23(38)12(2)47-32)33(50-20)48-15-7-16(35)21-17(36)9-18(49-19(21)8-15)13-3-5-14(34)6-4-13/h3-9,11-12,20,22-35,37-44H,10H2,1-2H3/t11-,12-,20+,22-,23-,24+,25+,26+,27-,28+,29+,30+,31+,32-,33+/m0/s1
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Ligustroflavone

1 Turpinia sp.

Biological Activity of Ligustroflavone

Description

Ligustroflavone shows high antioxidant capacity and is reported to be an AMPK activator, it activates AMPK by increasing ratio of AMP / ATP and promotes adiponectin multimerization by activating AMPK.

Targets

AMPK | ATP

In vitro

Studies on anti-complementary activity of extracts and isolated flavones from Ligustrum vulgare and Phillyrea latifolia leaves (Oleaceae).[Pubmed: 10837985]

J Ethnopharmacol. 2000 Jun;70(3):213-7.

METHODS AND RESULTS:
Polar fractions and flavones isolated from methanolic extracts of the leaves of Ligustrum vulgare and Phillyrea latifolia (Oleaceae), whose popular use as an anti-inflammatory is well-known in Mediterranean historical medicine and ethnobotany, showed significant in vitro complement inhibiting effect on the classical pathway of the complement system.
CONCLUSIONS:
Among the isolated flavonoidic structures, apigenin-7-O-glucoside, apigenin-7-O-rutinoside, luteolin-4'-O-glucoside, luteolin-7-O-glucoside and Ligustroflavone presented remarkable activity.

Identification of Glycosil Flavones and Determination in vitro of Antioxidant and Photoprotective Activities of Alternanthera brasiliana L. Kuntze.[Reference: WebLink]

Research Journal of Phytochemistry, 2014, 8(4):148-154.

The study Alternanthera brasiliana (L.) Kuntze aims to prove its effectiveness in folk medicine.
METHODS AND RESULTS:
From the study of their chemical constitution were identified by LC-MS technique three glycosylated flavones than were called 2"-O-ramnosylvitexin; 4',5,7-trimethoxy-2"-Oramnosylvitexin and Ligustroflavone. The tests showed high antioxidant capacity of the specie and in small concentrations showed too high levels of photoprotection. In addition its high capacity for photoprotection also paves its use in cosmetology.
CONCLUSIONS:
Alternanthera brasiliana is a species extremely promising with all parameters to become a herbal medicine.

Protocol of Ligustroflavone

Kinase Assay

Assembly of Adiponectin with Ligustroflavone by Activating AMPK.[Reference: WebLink]

Chinese Journal of Experimental Traditional Medical Formulae, 2016(1):18-21.

To investigate activation mechanism of AMPK [adenosine 5'-monophosphate( AMP)-activated protein kinase] by Ligustroflavone,and explore effect of Ligustroflavone on assembly of adiponectin.
METHODS AND RESULTS:
293 T cells were treated with Ligustroflavone. AMPK phosphorylation and evel of cellular AMP and ATP were examined by western blotting and high performance liquid chromatography( HPLC),respectively. 3T3-L1 adipocyte was treated by Ligustroflavone and its effect on assembly of adiponectin was detected. Ligustroflavone can activate AMPK and increase ratio of AMP / ATP in 293 T cells.Ligustroflavone also can promote ssembly of adiponectin multimers.
CONCLUSIONS:
Ligustroflavone activates AMPK by increasing ratio of AMP / ATP and promotes adiponectin multimerization by activating AMPK.

Structure Identification

Pharmazie. 2000 Jan;55(1):78-80.

Isolation and structure elucidation of ligustroflavone, a new apigenin triglycoside from the leaves of Ligustrum vulgare L.[Pubmed: 10683879]

A new flavone, apigenin-7-O-beta-(2",6"-di-alpha-rhamnopyranosyl)-glucopyranoside , named Ligustroflavone, was isolated from the leaves of common privet (Ligustrum vulgare L., Oleaceae), whose popular use was well known in the Mediterranean historical medicine and ethnomedicine as anti-inflammatory. The structures of other five apigenin and luteolin derivates, isolated from the polar fractions of the methanolic leaf extracts, were elucidated.

Preparing Stock Solutions of Ligustroflavone

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.3799 mL	6.8997 mL	13.7994 mL	27.5988 mL	34.4985 mL
5 mM	0.276 mL	1.3799 mL	2.7599 mL	5.5198 mL	6.8997 mL
10 mM	0.138 mL	0.69 mL	1.3799 mL	2.7599 mL	3.4498 mL
50 mM	0.0276 mL	0.138 mL	0.276 mL	0.552 mL	0.69 mL
100 mM	0.0138 mL	0.069 mL	0.138 mL	0.276 mL	0.345 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.