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Keywords
- Buy High quality of vitexin
- Hot sale vitexin
- standard supplier vitexin in China
Quick Details
- ProName: vitexin
- CasNo: 3681-93-4
- Molecular Formula: C21H20O10=432.38
- Appearance: detailed see specifications
- Application: analysis,activity test,Botanical Refer...
- DeliveryTime: 1-3?working?days?after?confirming?the?...
- PackAge: According to the clients requirement.
- Port: China main port
- ProductionCapacity: 1 Metric Ton/Day
- Purity: ≥98%
- Storage: Store at 2~8°C
- Transportation: by air or by ocean shipping
- LimitNum: 10 Milligram
- Plant of Origin: Chinese herbal medicine
- Testing Method: NMR/MS/HPLC
- Product Ecification: 1mg-1kg
- Heavy Metal: <10ppm
- Voluntary Standards: company standard
- Storage: Store in dry, dark and ventilated plac...
- PackAge: Brown vial HDPE plastic bottle
Superiority
Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.
Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library
1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging:1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition:Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.
Details
Chemical Properties of Vitexin
Cas No. | 3681-93-4 | SDF | |
PubChem ID | 5280441 | Appearance | Yellow powder |
Formula | C21H20O10 | M.Wt | 432.4 |
Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
Synonyms | Apigenin 8-C-glucoside; 8-C-Glucosylapigenin; Orientoside; 4',5,7-Trihydroxyflavone 8-C-glucoside | ||
Solubility | DMSO : 62.5 mg/mL (144.55 mM; Need ultrasonic) | ||
Chemical Name | 5,7-dihydroxy-2-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one | ||
SMILES | C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)C4C(C(C(C(O4)CO)O)O)O)O | ||
Standard InChIKey | SGEWCQFRYRRZDC-VPRICQMDSA-N | ||
Standard InChI | InChI=1S/C21H20O10/c22-7-14-17(27)18(28)19(29)21(31-14)16-11(25)5-10(24)15-12(26)6-13(30-20(15)16)8-1-3-9(23)4-2-8/h1-6,14,17-19,21-25,27-29H,7H2/t14-,17-,18+,19-,21+/m1/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Source of Vitexin
1 Adonis sp. 2 Ailanthus sp. 3 Arum sp. 4 Cannabis sp. 5 Capsicum sp. 6 Carlina sp. 7 Chamaecytisus sp. 8 Crataegus sp. 9 Fagopyrum sp. 10 Glycine sp. 11 Glycyrrhiza sp. 12 Helenium sp. 13 Hevea sp. 14 Humulus sp. 15 Jatropha sp. 16 Lavandula sp. 17 Lemna sp. 18 Linum sp. 19 Lycopus sp. 20 Lythrum sp. 21 Ononis sp. 22 Origanum sp. 23 Passiflora sp. 24 Persicaria sp. 25 Phaseolus sp. 26 Polygonum sp. 27 Ruscus sp. 28 Tamarindus sp. 29 Trigonella sp. 30 Viola sp. 31 Vitex sp. 32 Zanthoxylum sp.
Biological Activity of Vitexin
Description | Vitexin, an HIF-1alpha inhibitor, which has anticonvulsant, anti-depressant, anti-glycation, spasmolytic, anti-metastatic, antitumor, anti-inflammatory and antinociceptive activities. Vitexin can be effectively used for the prevention of UV-induced adverse skin reactions such as free radical production and skin cell damage; it non-competitively inhibits Ach but not the Ca(2+) influx. |
Targets | 5-HT Receptor | P450 (e.g. CYP17) | ERK | JNK | Bcl-2/Bax | p38MAPK | TRPV | TNF-α | IL Receptor | HIF | VEGFR | Calcium Channel |
In vitro |
The isolation and antioxidative effects of vitexin from Acer palmatum.[Pubmed: 15789751] Arch Pharm Res. 2005 Feb;28(2):195-202. Free radicals and reactive oxygen species (ROS) caused by UV exposure or other environmental factors are critical players in cellular damage and aging. |
In vivo |
Anti-depressant-like effect of vitexin in BALB/c mice and evidence for the involvement of monoaminergic mechanisms.[Pubmed: 23099258 ] Eur J Pharmacol. 2013 Jan 15;699(1-3):250-7. The present study was designed to investigate the putative effect of Vitexin, a flavone C-glucoside present in some drugs, medicinal plants and nutraceuticals, on the central nervous system. Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines.[Pubmed: 23742617] J Nat Prod. 2013 Jun 28;76(6):1141-9. The flavonoid Vitexin (1) is a flavone C-glycoside (apigenin-8-C-β-D-glucopyranoside) present in several medicinal and other plants. Plant extracts containing 1 are reported to possess antinociceptive, anti-inflammatory, and antioxidant activities. However, the only evidence that 1 exhibits antinociceptive activity was demonstrated in the acetic acid-induced writhing model. Therefore, the analgesic effects and mechanisms of 1 were evaluated. The spasmolytic effect of Aloysia citriodora, Palau (South American cedrón) is partially due to its vitexin but not isovitexin on rat duodenums.[Pubmed: 17640836 ] J Ethnopharmacol. 2007 Sep 5;113(2):258-66. The spasmolytic effects of an acqueous extract of cedrón (AEC) were studied on rat isolated duodenums. This plant (Aloysia citriodora Palau, Verbenaceae) is widely used for gastrointestinal disorders and as eupeptic in South America. |
Protocol of Vitexin
Kinase Assay |
Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth.[Pubmed: 19671865] Vitexin, an HIF-1alpha inhibitor, has anti-metastatic potential in PC12 cells.[Pubmed: 17202857] Mol Cells. 2006 Dec 31;22(3):291-9. Vitexin, a natural flavonoid compound identified as apigenin-8-C-b-D-glucopyranoside, has been reported to exhibit antioxidative and anti-inflammatory properties. Clin Cancer Res. 2009 Aug 15;15(16):5161-9. Lignans such as secoisolariciresinol diglucoside in flaxseed, are metabolizes to bioactive mammalian lignans of END and ENL. Because mammalian lignans have chemical structural similarity to the natural estrogen, they are thought to behave like selective estrogen receptor modulators and therefore have anticancer effect against hormone-related cancers. We isolated a series of lignan compounds, named as Vitexins, from the seed of Chinese herb Vitex Negundo. |
Animal Research |
Neuroprotective effects of vitexin, a flavonoid, on pentylenetetrazole-induced seizure in rats.[Pubmed: 22554436] Vitexin protects brain against ischemia/reperfusion injury via modulating mitogen-activated protein kinase and apoptosis signaling in mice.[Pubmed: 25837275] Phytomedicine. 2015 Mar 15;22(3):379-84. Vitexin is a major bioactive flavonoid compound derived from the dried leaf of hawthorn (Crataegus pinnatifida), a widely used conventional folk medicine in China. Recent studies have shown that Vitexin presents neuroprotective effects in vitro. Whether this protective effect applies to the cerebral ischemia/reperfusion (I/R) injury remains elusive. Chem Biol Drug Des. 2012 Aug;80(2):274-8. Flavonoids are important constituents of food and beverages and have several neuropharmacological activities. Many of these compounds are ligands for γ-aminobutyric acid type A receptors in the central nervous system. |
Structure Identification |
Food Chem., 2008, 106(2):475-81. Inhibitory effect of mung bean extract and its constituents vitexin and isovitexin on the formation of advanced glycation endproducts.[Reference: WebLink] The anti-glycation activity of four kinds of beans including mung bean, black bean, soybean and cowpea were evaluated. |
Preparing Stock Solutions of Vitexin
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.3127 mL | 11.5634 mL | 23.1267 mL | 46.2535 mL | 57.8168 mL |
5 mM | 0.4625 mL | 2.3127 mL | 4.6253 mL | 9.2507 mL | 11.5634 mL |
10 mM | 0.2313 mL | 1.1563 mL | 2.3127 mL | 4.6253 mL | 5.7817 mL |
50 mM | 0.0463 mL | 0.2313 mL | 0.4625 mL | 0.9251 mL | 1.1563 mL |
100 mM | 0.0231 mL | 0.1156 mL | 0.2313 mL | 0.4625 mL | 0.5782 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentration |