Securinine CAS NO.5610-40-2

Min.Order: 10 Milligram
Payment Terms: T/T
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Securinine
5610-40-2
standard supplier in China

Quick Details

ProName: Securinine
CasNo: 5610-40-2
Molecular Formula: C13H15NO2
Appearance: detailed see specifications
Application: analysis,activity test,Botanical Refer...
DeliveryTime: 1-3?working?days?after?confirming?the?...
PackAge: According to the clients requirement.
Port: China main port
ProductionCapacity: 1 Metric Ton/Day
Purity: 98%
Storage: keep sealed and keep from direct light
Transportation: by air or by ocean shipping
LimitNum: 10 Milligram
Plant of Origin: Chinese herbal medicine
Testing Method: NMR/MS/HPLC
Product Ecification: 1mg-1kg
Heavy Metal: <10ppm
Voluntary Standards: company standard
Storage: Brown vial HDPE plastic bottle

Superiority

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.

Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library

1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries
General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Details

Chemical Properties of Securinine

Cas No.	5610-40-2	SDF
PubChem ID	201912	Appearance	Light yellow powder
Formula	C₁₃H₁₅NO₂	M.Wt	217.26
Type of Compound	Alkaloids	Storage	Desiccate at -20°C
Solubility	DMSO : 2 mg/mL (9.21 mM; Need ultrasonic)
SMILES	C1CCN2C(C1)C34CC2C=CC3=CC(=O)O4.[N+](=O)(O)[O-]
Standard InChIKey	GTMBYDCKQUSFCT-DGKOSOBHSA-N
Standard InChI	InChI=1S/C13H15NO2.HNO3/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11;2-1(3)4/h4-5,7,10-11H,1-3,6,8H2;(H,2,3,4)/t10-,11+,13?;/m0./s1
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Securinine

1 Securinega sp.

Biological Activity of Securinine

Description	1. Securinine induces apoptosis in human leukemia HL-60 cells. 2. Securinine is a promising new monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML) . 3. Securinine, a GABAA receptor antagonist, enhances macrophage clearance of phase II C. burnetii: comparison with TLR agonists. 4. Securinine shows antifungal activity against some plant pathogenic fungi.
Targets	TLR \| IL Receptor \| GABA Receptor

Preparing Stock Solutions of Securinine

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.6028 mL	23.0139 mL	46.0278 mL	92.0556 mL	115.0695 mL
5 mM	0.9206 mL	4.6028 mL	9.2056 mL	18.4111 mL	23.0139 mL
10 mM	0.4603 mL	2.3014 mL	4.6028 mL	9.2056 mL	11.507 mL
50 mM	0.0921 mL	0.4603 mL	0.9206 mL	1.8411 mL	2.3014 mL
100 mM	0.046 mL	0.2301 mL	0.4603 mL	0.9206 mL	1.1507 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on Securinine

Securinine induced apoptosis in human leukemia HL-60 cells.[Pubmed:10452105]

Zhongguo Yao Li Xue Bao. 1999 Mar;20(3):267-70.

AIM: To study whether Securinine might induce apoptosis in human leukemia HL-60 cells. METHODS: Inhibition of proliferation was measured using MTT assay. The amount of apoptotic cells was measured by flow cytometry. DNA fragmentation was visualized by DNA agarose gel electrophoresis and the cellular changes were observed by electron microscope. RESULTS: Securinine 5-80 mg.L-1 elicited typical apoptosis morphological changes and DNA fragmentation in a concentration-dependent manner in HL-60 cells. Securinine inhibited HL-60 cell proliferation in a time- and concentration-dependent manner. The IC50 and 95% confidence limits were 27 (15-47) mg.L-1 after 12-h treatment with Securinine. CONCLUSION: Securinine induced apoptosis in HL-60 cells.

Antifungal Activity of Securinine against Some Plant Pathogenic Fungi.[Pubmed:23990741]

Mycobiology. 2008 Jun;36(2):99-101.

The alkaloid Securinine was assessed against spore germination of some plant pathogenic and saprophytic fungi (Alternaria alternata, Alternaria brassicae, Alternaria brassicicola, Curvularia lunata, Curvularia maculans, Curvularia pallenscens, Colletotrichum musae, Colletotrichum sp., Erysiphe pisi, Helminthosporium echinoclova, Helminthosporium spiciferum, Heterosporium sp.). Spore germinations of all the tested fungi were inhibited. Alternaria brassicicola, C. lunata, C. pallenscens and H. spiciferum were highly sensitive as complete inhibition of spore germination was observed at very low concentrations (200 ppm).

Securinine, a myeloid differentiation agent with therapeutic potential for AML.[Pubmed:21731671]

PLoS One. 2011;6(6):e21203.

As the defining feature of Acute Myeloid Leukemia (AML) is a maturation arrest, a highly desirable therapeutic strategy is to induce leukemic cell maturation. This therapeutic strategy has the potential of avoiding the significant side effects that occur with the traditional AML therapeutics. We identified a natural compound Securinine, as a leukemia differentiation-inducing agent. Securinine is a plant-derived alkaloid that has previously been used clinically as a therapeutic for primarily neurological related diseases. Securinine induces monocytic differentiation of a wide range of myeloid leukemia cell lines as well as primary leukemic patient samples. Securinine's clinical potential for AML can be seen from its ability to induce significant growth arrest in cell lines and patient samples as well as its activity in significantly impairing the growth of AML tumors in nude mice. In addition, Securinine can synergize with currently employed agents such as ATRA and decitabine to induce differentiation. This study has revealed Securinine induces differentiation through the activation of DNA damage signaling. Securinine is a promising new monocytic differentiation inducing agent for AML that has seen previous clinical use for non-related disorders.

Description

(-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.