Ganoderiol D CAS NO.114567-45-2

Min.Order: 10 Milligram
Payment Terms: T/T
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Ganoderiol D
114567-45-2
standard supplier in China

Quick Details

ProName: Ganoderiol D
CasNo: 114567-45-2
Molecular Formula: C30H48O5=488.7
Appearance: detailed see specifications
Application: analysis,activity test,Botanical Refer...
DeliveryTime: 1-3?working?days?after?confirming?the?...
PackAge: According to the clients requirement.
Port: China main port
ProductionCapacity: 1 Metric Ton/Day
Purity: ≥98%
Storage: Store at 2~8°C
Transportation: by air or by ocean shipping
LimitNum: 10 Milligram
Plant of Origin: Chinese herbal medicine
Testing Method: NMR/MS/HPLC
Product Ecification: 1mg-1kg
Heavy Metal: <10ppm
Voluntary Standards: company standard
Storage: Store in dry, dark and ventilated plac...
PackAge: Brown vial HDPE plastic bottle

Superiority

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.

Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library

1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries

General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Details

Chemical Properties of Ganoderiol D

Cas No.	114567-45-2
PubChem ID	15602261	Appearance	Powder
Formula	C₃₀H₄₈O₅	M.Wt	488.7
Type of Compound	Triterpenoids	Storage	Desiccate at -20°C
Solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name	4,4,10,13,14-pentamethyl-17-(5,6,7-trihydroxy-6-methylheptan-2-yl)-2,5,6,11,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthrene-3,7-dione
SMILES	CC(CCC(C(C)(CO)O)O)C1CCC2(C1(CCC3=C2C(=O)CC4C3(CCC(=O)C4(C)C)C)C)C
Standard InChIKey	NAETYGPWGSNZTO-UHFFFAOYSA-N
Standard InChI	InChI=1S/C30H48O5/c1-18(8-9-24(34)30(7,35)17-31)19-10-15-29(6)25-20(11-14-28(19,29)5)27(4)13-12-23(33)26(2,3)22(27)16-21(25)32/h18-19,22,24,31,34-35H,8-17H2,1-7H3
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Ganoderiol D

The fruit body of Ganoderma lucidum

Preparing Stock Solutions of Ganoderiol D

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0462 mL	10.2312 mL	20.4625 mL	40.9249 mL	51.1561 mL
5 mM	0.4092 mL	2.0462 mL	4.0925 mL	8.185 mL	10.2312 mL
10 mM	0.2046 mL	1.0231 mL	2.0462 mL	4.0925 mL	5.1156 mL
50 mM	0.0409 mL	0.2046 mL	0.4092 mL	0.8185 mL	1.0231 mL
100 mM	0.0205 mL	0.1023 mL	0.2046 mL	0.4092 mL	0.5116 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on Ganoderiol D

Lanostane triterpenoids from the fruiting bodies of Ganoderma hainanense and their cytotoxic activity.[Pubmed:35771834]

J Asian Nat Prod Res. 2022 Jun 30:1-7.

Three undescribed lanostane triterpenoids, 24E-en-11-oxo-Ganoderiol D (1), 11beta-hydroxy-Ganoderiol D (2), and 11beta-hydroxy-lucidone H (3) were isolated from the 80% EtOH extract of the fruiting bodies of Ganoderma hainanense. Structural elucidation of all the compounds were performed by spectral methods such as 1 D and 2 D ((1)H-(1)H COSY, HMQC, and HMBC) NMR spectroscopy. All the triterpenoids were in vitro evaluated for their cytotoxic activities against six mammary adenocarcinoma cell lines (MCF7, MDA-MB-231, SK-BR-3, BT-20, HCC38, and AU565). As a result, compound 3 exhibited significant cytotoxic activities against all tested cell lines with IC(50) values less than 20 muM.

Antimicrobial lanostane triterpenoids from the fruiting bodies of Ganoderma applanatum.[Pubmed:34923886]

J Asian Nat Prod Res. 2022 Nov;24(11):1001-1007.

A chemical investigation on the 90% EtOH extract of the fruiting bodies of Ganoderma applanatum led to the isolation of three new lanostane triterpenoids, designated as 25-methoxy-11-oxo-Ganoderiol D (1), 3-oxo-25-methoxy-24,26-dihydroxy-lanosta-7,9(11)-diene (2), and 3beta-acetyloxy-lucidone H (3). Structural elucidation of all the compounds were performed by spectral methods such as 1 D and 2 D ((1)H-(1)H COSY, HMQC, and HMBC) NMR spectroscopy. All the triterpenoids were in vitro evaluated for their antimicrobial activities against six pathogenic microorganisms. Compounds 1 and 2 exhibited some activities against three Gram positive bacteria with MIC values less than 60 mug/ml.

Lanostanoids with acetylcholinesterase inhibitory activity from the mushroom Haddowia longipes.[Pubmed:25577284]

Phytochemistry. 2015 Feb;110:133-9.

Nine lanostanoids, together with nine known ones, were isolated from the ethyl acetate extract of the fruiting bodies of the mushroom Haddowia longipes. Their structures were elucidated as 11-oxo-Ganoderiol D, lanosta-8-en-7,11-dioxo-3beta-acetyloxy-24,25,26-trihydroxy, lanosta-8-en-7-oxo-3beta-acetyloxy-11beta,24,25,26-tetrahydroxy, lanosta-7,9(11)-dien-3beta-acetyloxy-24,25,26-trihydroxy, lanosta-7,9(11)-dien-3beta-acetyloxy-24,26-dihydroxy-25-methoxy, 11-oxo-lucidadiol, 11beta-hydroxy-lucidadiol, lucidone H and lanosta-7,9(11),24E-trien-3beta-acetyloxy-26,27-dihydroxy by analysing their 1D/2D NMR and MS spectra. In addition, bioassays of inhibitory activity against acetylcholinesterase (AChE) of all compounds showed that thirteen compounds possessed inhibitory activity against AChE with the percentage inhibition ranging from 10.3% to 42.1% when tested at 100 muM.

Triterpene-farnesyl hydroquinone conjugates from Ganoderma sinense.[Pubmed:19331378]

J Nat Prod. 2009 May 22;72(5):958-61.

Three new lanostane-type triterpenoids having farnesyl hydroquinone moieties, named ganosinensins A-C (1-3), were isolated from the fruiting body of Ganoderma sinense, together with three known lanostane triterpenes, ganodermanontriol, ganoderiol A, and Ganoderiol D. The structures of compounds 1-3 were determined by spectroscopic data interpretation.

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