DL-Isoborneol CAS NO.124-76-5

Min.Order: 10 Milligram
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DL-Isoborneol
124-76-5
standard supplier in China

Quick Details

ProName: DL-Isoborneol
CasNo: 124-76-5
Molecular Formula: C10H18O
Appearance: detailed see specifications
Application: analysis,activity test,Botanical Refer...
DeliveryTime: 1-3?working?days?after?confirming?the?...
PackAge: According to the clients requirement.
Port: China main port
ProductionCapacity: 1 Metric Ton/Day
Purity: 98%
Storage: keep sealed and keep from direct light
Transportation: by air or by ocean shipping
LimitNum: 10 Milligram
Plant of Origin: Chinese herbal medicine
Testing Method: NMR/MS/HPLC
Product Ecification: 1mg-1kg
Heavy Metal: <10ppm
Voluntary Standards: company standard
Storage: Brown vial HDPE plastic bottle

Superiority

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.

Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library

1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries

General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Details

Chemical Properties of Isoborneol

Cas No.	124-76-5	SDF
PubChem ID	6321405	Appearance	Powder
Formula	C₁₀H₁₈O	M.Wt	154.3
Type of Compound	Monoterpenoids	Storage	Desiccate at -20°C
Solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name	(1R,2R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol
SMILES	CC1(C2CCC1(C(C2)O)C)C
Standard InChIKey	DTGKSKDOIYIVQL-MRTMQBJTSA-N
Standard InChI	InChI=1S/C10H18O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7-8,11H,4-6H2,1-3H3/t7-,8-,10+/m1/s1
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Isoborneol

The leaves of Blumea balsamifera.

Biological Activity of Isoborneol

Description

Isoborneol shows neuroprotective, antioxidant, and repellent effects, it shows dual viricidal activity against herpes simplex virus 1 (HSV-1).

Targets

HSV | Bcl-2/Bax | Caspase | PKC | JNK | ROS

In vitro

Antiviral properties of isoborneol, a potent inhibitor of herpes simplex virus type 1.[Pubmed: 10517310]

Antiviral Res. 1999 Sep;43(2):79-92.

Isoborneol, a monoterpene and a component of several plant essential oils, showed dual viricidal activity against herpes simplex virus 1 (HSV-1).
METHODS AND RESULTS:
First, it inactivated HSV-1 by almost 4 log10 values within 30 min of exposure, and second, Isoborneol at a concentration of 0.06% completely inhibited viral replication, without affecting viral adsorption. Isoborneol did not exhibit significant cytotoxicity at concentrations ranging between 0.016% and 0.08% when tested against human and monkey cell lines. Isoborneol specifically inhibited glycosylation of viral polypeptides based on the following data: (1) the mature fully glycosylated forms of two viral glycoproteins gB and gD were not detected when the virus was replicated in the presence of Isoborneol, (2) no major changes were observed in the glycosylation pattern of cellular polypeptides between untreated and Isoborneol treated Vero cells, (3) Isoborneol did not affect the glycosylation of gB produced from a copy of the gB gene resident in the cellular genome, and (4) other monoterpenes such as 1,8-cineole and borneol, a stereoisomer of Isoborneol, did not inhibit HSV-1 glycosylation.

Repellent effects of isoborneol on subterranean termites (Isoptera: Rhinotermitidae) in soils of different composition[Pubmed: 14503600]

J Econ Entomol. 2003 Aug;96(4):1267-74.

METHODS AND RESULTS:
The repellence of the plant-derived bicyclic monoterpenoid Isoborneol on subterranean termites was assessed in short-term laboratory bioassays. Depending on concentration, application of Isoborneol to different soil types was efficient in creating repellent soil barriers, which were not penetrated by workers of Reticulitermes santonensis De Feytaud or R. flavipes Kollar within 2 wk after adding the substance to the substrate. Isoborneol-treated barriers did not affect termite survival. The bioavailability of the active ingredient decreased with increasing clay content of the soil.
CONCLUSIONS:
Evaporation of Isoborneol from treated soil increased with increasing particle size of the substrate and could be reduced by covering the soil surface.

Protocol of Isoborneol

Cell Research

Protective effect of (+/-) isoborneol against 6-OHDA-induced apoptosis in SH-SY5Y cells.[Pubmed: 17975304 ]

Cell Physiol Biochem. 2007;20(6):1019-32.

Oxidative stress caused by dopamine (DA) may play an important role in the pathogenesis of Parkinson's disease (PD). (+/-) Isoborneol is a monoterpenoid alcohol present in the essential oils of numerous medicinal plants and is a known antioxidant.
METHODS AND RESULTS:
In this study, we investigated the neuroprotective effect of Isoborneol against 6-hydroxydopamine (6-OHDA)-induced cell death in human neuroblastoma SH-SY5Y cells. Pretreatment of SH-SY5Y cells with Isoborneol significantly reduced 6-OHDA-induced generation of reactive oxygen species (ROS) and 6-OHDA-induced increases in intracellular calcium. Furthermore, apoptosis induced by 6-OHDA was reversed by Isoborneol treatment. Isoborneol protected against 6-OHDA-induced increases in caspase-3 activity and cytochrome C translocation into the cytosol from mitochondria. Isoborneol prevented 6-OHDA from decreasing the Bax/Bcl-2 ratio. We also observed that Isoborneol decreased the activation of c-Jun N-terminal kinase and induced activation of protein kinase C (PKC) which had been suppressed by 6-OHDA.
CONCLUSIONS:
Our results indicate that the protective function of Isoborneol is dependent upon its antioxidant potential and strongly suggest that Isoborneol may be an effective treatment for neurodegenerative diseases associated with oxidative stress.

Structure Identification

Asian Journal of Chemistry, 2014, 26(4):997-1001.

Determination of (-)-Borneol, Camphor and Isoborneol in Blumea balsamifera (L.) DC. Leaves by Simultaneous Ultrasonic and Microwave Assisted Extraction and Gas Chromatography[Reference: WebLink]

METHODS AND RESULTS:
In present work, simultaneous ultrasonic and microwave assisted extraction followed by GC-FID was developed for quantitative analysis of the bioactive components of (-)-borneol, camphor and Isoborneol in Blumea balsamifera leaves. After systematical investigation, the optimal experimental parameters microwave power (100 W) and extraction time (30 s) were investigated. The optimized method provided satisfactory linearity, precision, stability and recovery. The proposed method was applied for determination of three target compounds in leaves samples from 14 different times of harvest period. The variations of three target compounds were monitored and the result demonstrates (-)-borneol content of leaves was higher level from mid-October to next January.
CONCLUSIONS:
It has been shown that the proposed ultrasonic and microwave assisted extraction-GC-FID is a simple, rapid and reliable method for quantitative analysis of (-)-borneol, camphor and Isoborneol in B. balsamifera leaves and a potential tool for quality assessment of B. balsamifera leaves.

Preparing Stock Solutions of Isoborneol

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.4809 mL	32.4044 mL	64.8088 mL	129.6176 mL	162.022 mL
5 mM	1.2962 mL	6.4809 mL	12.9618 mL	25.9235 mL	32.4044 mL
10 mM	0.6481 mL	3.2404 mL	6.4809 mL	12.9618 mL	16.2022 mL
50 mM	0.1296 mL	0.6481 mL	1.2962 mL	2.5924 mL	3.2404 mL
100 mM	0.0648 mL	0.324 mL	0.6481 mL	1.2962 mL	1.6202 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.