- Product Details
Keywords
- Asiaticoside
- 16830-15-2
- standard supplier in China
Quick Details
- ProName: Asiaticoside
- CasNo: 16830-15-2
- Molecular Formula: C48H78O19=959.12
- Appearance: detailed see specifications
- Application: analysis,activity test,Botanical Refer...
- DeliveryTime: 1-3?working?days?after?confirming?the?...
- PackAge: According to the clients requirement.
- Port: China main port
- ProductionCapacity: 1 Metric Ton/Day
- Purity: ≥98%
- Storage: Store at 2~8°C
- Transportation: by air or by ocean shipping
- LimitNum: 10 Milligram
- Plant of Origin: Chinese herbal medicine
- Testing Method: NMR/MS/HPLC
- Product Ecification: 1mg-1kg
- Heavy Metal: <10ppm
- Voluntary Standards: company standard
- Storage: Store in dry, dark and ventilated plac...
- PackAge: Brown vial HDPE plastic bottle
Superiority
Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.
Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library
1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging:1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition:Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.
Details
Chemical Properties of Asiaticoside
Cas No. | 16830-15-2 | SDF | |
PubChem ID | 5351525 | Appearance | White powder |
Formula | C48H78O19 | M.Wt | 959.12 |
Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
Synonyms | Madecassol | ||
Solubility | DMSO : 50 mg/mL (52.13 mM; Need ultrasonic) | ||
Chemical Name | [6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl] (1S,2R,4aS,6aS,6bR,9R,10S,11R,12aR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate | ||
SMILES | CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CC(C(C5(C)CO)O)O)C)C)C2C1C)C)C(=O)OC6C(C(C(C(O6)COC7C(C(C(C(O7)CO)OC8C(C(C(C(O8)C)O)O)O)O)O)O)O)O | ||
Standard InChIKey | WYQVAPGDARQUBT-NNUNPJGWSA-N | ||
Standard InChI | InChI=1S/C48H78O19/c1-20-10-13-48(15-14-46(6)23(29(48)21(20)2)8-9-28-44(4)16-24(51)39(60)45(5,19-50)27(44)11-12-47(28,46)7)43(61)67-42-36(58)33(55)31(53)26(65-42)18-62-40-37(59)34(56)38(25(17-49)64-40)66-41-35(57)32(54)30(52)22(3)63-41/h8,20-22,24-42,49-60H,9-19H2,1-7H3/t20-,21+,22?,24-,25?,26?,27?,28?,29+,30?,31?,32?,33?,34?,35?,36?,37?,38?,39-,40?,41?,42?,44+,45+,46-,47-,48+/m1/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Source of Asiaticoside
1 Punica sp. 2 Shorea sp.
Biological Activity of Asiaticoside
Description | Asiaticoside, a biochemical modulator, which has antioxidant, anti-inflammatory, antipyretic, anxiolytic-like, anti-gastric ulcers, hepatoprotective, and antidepressant-like effects, it also exhibits significant wound healing activity in normal as well as delayed healing models. Asiaticoside suppressed collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts. It and its derivatives can be regarded as reasonable candidates for a therapeutic Alzheimer's disease drug that protects neurons from Abeta toxicity. |
Targets | NF-kB | TNF-α | IL Receptor | p65 | IkB | TGF-β/Smad | p38MAPK | JNK | ERK | Caspase | COX | PGE | PPAR | NOS | Bcl-2/Bax | Beta Amyloid | IKK |
In vitro |
Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts.[Pubmed: 21240513 ] Arch Dermatol Res. 2011 Oct;303(8):563-72. Asiaticoside (ATS) isolated from the leaves of Centella asiatica possesses strong wound-healing properties and reduces scar formation. However, the specific effects of Asiaticoside on the formation of keloidal scars remain unknown. Antipyretic and anti-inflammatory effects of asiaticoside in lipopolysaccharide-treated rat through up-regulation of heme oxygenase-1.[Pubmed: 22972613 ] Phytother Res. 2013 Aug;27(8):1136-42. Asiaticoside (AS), a triterpenoid isolated from Centella asiatica, has been found to exhibit antioxidant and anti-inflammatory activities in several experimental animal models. However, the underlying mechanisms remain elusive. |
In vivo |
In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica.[Pubmed: 10350364] J Ethnopharmacol. 1999 Apr;65(1):1-11. The activity of Asiaticoside, isolated from Centella asiatica, has been studied in normal as well as delayed-type wound healing. Asiaticoside attenuates lipopolysaccharide-induced acute lung injury via down-regulation of NF-κB signaling pathway.[Pubmed: 25835778] Int Immunopharmacol. 2015 May;26(1):181-7. Asiaticoside (AS), a triterpene glycoside isolated from Centella asiatica, has been shown to possess potent anti-inflammatory activity. However, the detailed molecular mechanisms of AS on lipopolysaccharide (LPS)-induced acute lung injury (ALI) model in mice are scanty. The purpose of this study was to evaluate the effect of AS on LPS-induced mouse ALI via down-regulation of NF-κB signaling pathway. Antidepressant-like effect of asiaticoside in mice.[Pubmed: 18325568 ] Pharmacol Biochem Behav. 2008 May;89(3):444-9.
Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide/D-galactosamine in mice.[Pubmed: 20171071 ] Phytomedicine. 2010 Aug;17(10):811-9. Asiaticoside (AS), a triterpenoid product isolated from Centella asiatica, has been described to exhibit anti-in fl ammatory activities in several inflammatory models. However, the effects of AS on liver injury are poorly understood. |
Protocol of Asiaticoside
Cell Research |
Asiaticoside inducing apoptosis of tumor cells and enhancing anti-tumor activity of vincristine.[Pubmed: 15601545] Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity.[Pubmed: 10518115] J Neurosci Res. 1999 Nov 1;58(3):417-25. Asiaticoside (AS) derivatives were tested for potential protective effects against Abeta-induced cell death. Of the 28 AS derivatives tested, asiatic acid (AA), Asiaticoside 6 (AS6), and SM2 showed strong inhibition of Abeta-induced death of B103 cells at 1 microM. Ai Zheng. 2004 Dec;23(12):1599-604. Asiaticoside (ATS), a triterpene extracted from Centella asiatica (L.) Urban, a traditional Chinese herb, possesses good wound healing activities because of its stimulative effect on collagen synthesis. Recently, the anti-tumor effect of asiaticiside has been reported. This study was to examine the induction of apoptosis in cancer cells, and the enhancement of vincristine (VCR) cytotoxicity by Asiaticoside. |
Animal Research |
Protective effects of asiaticoside on septic lung injury in mice.[Pubmed: 20471230 ] Anxiolytic-like effect of asiaticoside in mice.[Pubmed: 17059844] The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats.[Pubmed: 14987949 ] Life Sci. 2004 Mar 19;74(18):2237-49.
Pharmacol Biochem Behav. 2006 Oct;85(2):339-44. The putative anxiolytic activity of Asiaticoside was examined in male mice by using a number of experimental paradigms of anxiety, with diazepam being as a positive anxiolytic control. Exp Toxicol Pathol. 2011 Sep;63(6):519-25. Asiaticoside (AS), a major triterpenoid saponin component isolated from Centella asiatica, has been described to exhibit antioxidant and anti-inflammatory activities. |
Preparing Stock Solutions of Asiaticoside
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 1.0426 mL | 5.2131 mL | 10.4262 mL | 20.8524 mL | 26.0656 mL |
5 mM | 0.2085 mL | 1.0426 mL | 2.0852 mL | 4.1705 mL | 5.2131 mL |
10 mM | 0.1043 mL | 0.5213 mL | 1.0426 mL | 2.0852 mL | 2.6066 mL |
50 mM | 0.0209 mL | 0.1043 mL | 0.2085 mL | 0.417 mL | 0.5213 mL |
100 mM | 0.0104 mL | 0.0521 mL | 0.1043 mL | 0.2085 mL | 0.2607 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |