Pedunculoside CAS NO.42719-32-4

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General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
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Chemical Properties of Pedunculoside

Source of Pedunculoside

The barks of Ilex rotunda Thunb.

Biological Activity of Pedunculoside

Protocol of Pedunculoside

Preparing Stock Solutions of Pedunculoside

References on Pedunculoside

Enrichment and purification of pedunculoside and syringin from the barks of Ilex rotunda with macroporous resins.[Pubmed:25104900]

J Liq Chromatogr Relat Technol. 2014 Feb 1;37(4):572-587.

Jiubiying, the dried barks of Ilex rotunda Thunb. (Aquifoliaceae), has been used as herbal tea and traditional Chinese medicine for heat-clearing, detoxifying, dehumidification, and odynolysis. Pedunculoside and syringin are two main bioactive components. For the new drug development, we tried to isolate and purify several chemical constituents from Jiubiying by high-speed counter-current chromatography (HSCCC). The two-phase solvent system used was composed of ethyl acetate-n-butanol-water (1:6:7, v/v/v). From 1.0 g of Jiubiying extracts syringaresinol 4',4''-bis-O-beta-D- glucopyranoside (I, 20.2 mg), syringin (II, 56.8 mg), sinapaldehyde glucoside (III, 26.2 mg), syringaresinol 4'-O-beta-D-glucopyranoside (IV, 20.4 mg), and Pedunculoside (V, 45.1 mg) were obtained by one run of TBE-1000A HSCCC machine with 1000 mL of column volume. Their structures were identified by IR, MS, and extensive NMR studies. Syringaresinol 4',4''-bis-O-beta-D-glucopyranoside (I) was isolated from this plant for the first time.

Inhibitory activity of chemical constituents from Arenaria serpyllifolia on nitric oxide production.[Pubmed:23670630]

Planta Med. 2013 May;79(8):687-92.

Five new compounds, including one new xanthone, 1-hydroxy-5-methoxyxanthone 6-O-beta-D-glucopyranoside (1), one new lignan, 3-(beta-D-glucopyranosyloxymethyl)-2-(4-hydroxy-3-methoxyphenyl)-5-(3-acetoxyprop yl)-7-methoxy-(2R,3S)-dihydrobenzofuran (2), and three new gamma-pyrones, japonicumone A 4'-O-beta-D-glucopyranoside (3), japonicumone B 3'-O-beta-D-glucopyranoside (4), and japonicumone B 4'-O-beta-D-glucopyranoside (5), together with eight known compounds (6-13) were isolated from the whole plants of Arenaria serpyllifolia. Their structures were elucidated on the basis of extensive spectroscopic analysis (UV, IR, HRESIMS, 1D- and 2D-NMR, and CD) as well as chemical methods. The isolated compounds were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages. Compounds 1-5, sacranoside A (9), and Pedunculoside (13) showed potential nitric oxide inhibitory activities with IC50 values ranging from 14.92 microM to 52.23 microM.

A water-soluble inclusion complex of pedunculoside with the polymer beta-cyclodextrin: a novel anti-inflammation agent with low toxicity.[Pubmed:25013908]

PLoS One. 2014 Jul 11;9(7):e101761.

More than 50% of new drug candidates in drug discovery are lipophilic and exhibit poor aqueous solubility, which results in poor bioavailability and a lack of dose proportionality. Here, we improved the solubility of Pedunculoside (PE) by generating a water-soluble inclusion complex composed of PE and the polymer beta-cyclodextrin (CDP). We characterized this novel complex by 1H NMR, FT-IR, UV-vis spectroscopy, powder X-ray diffractometry and thermogravimetric analysis. The ratio of beta-cyclodextrin (beta-CD) units in CDP to PE was determined to be 2ratio1. The KD value of the inclusion complex was determined to be 4.29x10(-3) mol*L(-1). In contrast to the low solubility of PE, the water-solubility of the PE-CDP complex was greatly enhanced. A preclinical toxicological study indicated that PE-CDP was well tolerated for a single administration. Importantly, the anti-inflammation potency of the PE-CDP complex was higher than that of PE. As a result, the formation of inclusion complexes by water-soluble CDP opens up possible aqueous applications of insoluble drug candidates in drug delivery.

Description

Pedunculoside is a main bioactive component isolated from Jiubiying. Pedunculoside exerts lipid-lowering effects partly through the regulation of lipogenesis and fatty acid β-oxidation.

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