Damnacanthal CAS NO.477-84-9

Min.Order: 10 Milligram
Payment Terms: T/T
Available Specifications:

Product Details

Keywords

477-84-9
Damnacanthal
High quality

Quick Details

ProName: Damnacanthal
CasNo: 477-84-9
Molecular Formula: C16H10O5
Appearance: detailed see specifications
Application: analysis,activity test,Botanical Refer...
DeliveryTime: 1-3 working days after confirming
PackAge: According to the clients requirement.
Port: China main port
ProductionCapacity: 1 Metric Ton/Day
Purity: HPLC≥98%
Storage: Store at 2~8°C
Transportation: by air or by ocean shipping
LimitNum: 10 Milligram
Plant of Origin: Chinese herbal medicine
Testing Method: NMR/MS/HPLC
Product Ecification: 1mg-1kg
Heavy Metal: <10ppm
Voluntary Standards: Company standard

Superiority

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.

Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library

1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries

General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Details

Chemical Properties of Damnacanthal

Cas No.	477-84-9	SDF
PubChem ID	2948	Appearance	Yellow powder
Formula	C₁₆H₁₀O₅	M.Wt	282.3
Type of Compound	Anthraquinones	Storage	Desiccate at -20°C
Solubility	Soluble to 25 mM in DMSO
Chemical Name	3-hydroxy-1-methoxy-9,10-dioxoanthracene-2-carbaldehyde
SMILES	COC1=C2C(=CC(=C1C=O)O)C(=O)C3=CC=CC=C3C2=O
Standard InChIKey	IPDMWUNUULAXLU-UHFFFAOYSA-N
Standard InChI	InChI=1S/C16H10O5/c1-21-16-11(7-17)12(18)6-10-13(16)15(20)9-5-3-2-4-8(9)14(10)19/h2-7,18H,1H3
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Damnacanthal

The fruit of Morinda citrifolia Linn.

Biological Activity of Damnacanthal

Description

1. Damnacanthal possesses anti-cancer property, can treat or prevent hepatocellular carcinoma through its inhibitory effects on the HGF/c-Met axis. 2. Damnacanthal inhibits mast cell activation induced by different stimuli and open a new window for the use of this compound as a mast cell stabilizer. 3. P53-mediated Damnacanthal induces apoptosis through the activation of p21 and caspase-7. 4. Damnacanthal possesses anti-inflammatory property, can inhibit the NF-κB/receptor-interacting protein-2/caspase-1 signal pathway by inhibiting p56lck tyrosine kinase . 5. Damnacanthal and noni extract supplements containing it could be potentially interesting for the treatment and/or chemoprevention of hepatocellular carcinoma through its inhibitory effects on the HGF/c-Met axis. 6. Damnacanthal has antinociceptive and anti-inflammatory actions in mice. 7. Damnacanthal can act as an immunomodulatory agent which may be very useful for maintaining a healthy immune system.

Targets

Preparing Stock Solutions of Damnacanthal

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5423 mL	17.7117 mL	35.4233 mL	70.8466 mL	88.5583 mL
5 mM	0.7085 mL	3.5423 mL	7.0847 mL	14.1693 mL	17.7117 mL
10 mM	0.3542 mL	1.7712 mL	3.5423 mL	7.0847 mL	8.8558 mL
50 mM	0.0708 mL	0.3542 mL	0.7085 mL	1.4169 mL	1.7712 mL
100 mM	0.0354 mL	0.1771 mL	0.3542 mL	0.7085 mL	0.8856 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.