- Product Details
Keywords
- Astragalin
- 480-10-4
- standard supplier in China
Quick Details
- ProName: Astragalin
- CasNo: 480-10-4
- Molecular Formula: C21H20O11=448.4
- Appearance: detailed see specifications
- Application: analysis,activity test,Botanical Refer...
- DeliveryTime: 1-3?working?days?after?confirming?the?...
- PackAge: According to the clients requirement.
- Port: China main port
- ProductionCapacity: 1 Metric Ton/Day
- Purity: ≥98%
- Storage: Store at 2~8°C
- Transportation: by air or by ocean shipping
- LimitNum: 10 Milligram
- Plant of Origin: Chinese herbal medicine
- Testing Method: NMR/MS/HPLC
- Product Ecification: 1mg-1kg
- Heavy Metal: <10ppm
- Voluntary Standards: company standard
- Storage: Store in dry, dark and ventilated plac...
- PackAge: Brown vial HDPE plastic bottle
Superiority
Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.
Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library
1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging:1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition:Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.
Details
Chemical Properties of Astragalin
Cas No. | 480-10-4 | SDF | |
PubChem ID | 5282102 | Appearance | Yellow powder |
Formula | C21H20O11 | M.Wt | 448.4 |
Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
Synonyms | Astragaline; 3-Glucosylkaempferol; Kaempferol 3-β-D-glucopyranoside | ||
Solubility | DMSO : ≥ 100 mg/mL (223.03 mM) *"≥" means soluble, but saturation unknown. |
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Chemical Name | 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one | ||
SMILES | C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O | ||
Standard InChIKey | JPUKWEQWGBDDQB-QSOFNFLRSA-N | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Source of Astragalin
1 Aesculus sp. 2 Allium sp. 3 Alkanna sp. 4 Arctium sp. 5 Asplenium sp. 6 Castanea sp. 7 Cichorium sp. 8 Cornus sp. 9 Cucurbita sp. 10 Cyamopsis sp. 11 Dionaea sp. 12 Equisetum sp. 13 Eriodictyon sp. 14 Eryngium sp. 15 Euphorbia sp. 16 Geranium sp. 17 Ginkgo sp. 18 Glycyrrhiza sp. 19 Gossypium sp. 20 Hamamelis sp. 21 Humulus sp. 22 Illicium sp. 23 Lamium sp. 24 Larix sp. 25 Laurus sp. 26 Liquidambar sp. 27 Liriodendron sp. 28 Menyanthes sp. 29 Oenothera sp. 30 Orchis sp. 31 Paeonia sp. 32 Phyllanthus sp. 33 Phytolacca sp. 34 Platanus sp. 35 Primula sp. 36 Rhamnus sp. 37 Ribes sp. 38 Rosa sp. 39 Sambucus sp. 40 Sanguisorba sp. 41 Senecio sp. 42 Serenoa sp. 43 Solidago sp. 44 Syzygium sp. 45 Tilia sp. 46 Trigonella sp. 47 Urtica sp. 48 Viburnum sp.
Biological Activity of Astragalin
Description | Astragalin (kaempferol-3-O-glucoside) is a flavonoid with anti-inflammatory activity, it inhibits the TLR4-mediated NF-κB and mitogen-activated protein kinases signaling pathways. Astragalin ameliorates oxidative stress-associated epithelial eosinophilia and apoptosis through disturbing TLR4-PKCβ2-NADPH oxidase-responsive signaling; it also can be effective in allaying ROS-promoted bronchial fibrosis through inhibiting autophagosome formation in airways. |
Targets | ROS | TLR | PKC | NADPH-oxidase | NF-kB | p38MAPK | IkB | VEGFR | IL Receptor | NO | PGE | NOS | COX | PPAR | JNK | TNF-α | p65 | IKK |
In vitro |
Inhibitory effects of astragalin on lipopolysaccharide-induced inflammatory response in mouse mammary epithelial cells.[Pubmed: 24972733] J Surg Res. 2014 Dec;192(2):573-81. Tea brewed from the leaves of persimmon or Rosa agrestis have several medical functions including treating allergy, antiatopic dermatitis, and anti-inflammatory effects. The objective of this study was to investigate the molecular mechanisms of Astragalin, a main flavonoid component isolated from these herbs, in modifying lipopolysaccharide (LPS)-induced signaling pathways in primary cultured mouse mammary epithelial cells (mMECs). Astragalin inhibits autophagy-associated airway epithelial fibrosis.[Pubmed: 25895672] Respir Res. 2015 Apr 21;16:51. Fibrotic remodeling of airway and lung parenchymal compartments is attributed to pulmonary dysfunction with an involvement of reactive oxygen species (ROS) in chronic lung diseases such as idiopathic pulmonary fibrosis and asthma. Astragalin inhibits airway eotaxin-1 induction and epithelial apoptosis through modulating oxidative stress-responsive MAPK signaling.[Pubmed: 25069610] BMC Pulm Med. 2014 Jul 29;14:122. Eotaxin proteins are a potential therapeutic target in treating the peribronchial eosinophilia associated with allergic airway diseases. Since inflammation is often associated with an increased generation of reactive oxygen species (ROS), oxidative stress is a mechanistically imperative factor in asthma. Astragalin (kaempferol-3-O-glucoside) is a flavonoid with anti-inflammatory activity and newly found in persimmon leaves and green tea seeds. This study elucidated that Astragalin inhibited endotoxin-induced oxidative stress leading to eosinophilia and epithelial apoptosis in airways. |
Protocol of Astragalin
Cell Research |
Astragalin inhibits IL-1β-induced inflammatory mediators production in human osteoarthritis chondrocyte by inhibiting NF-κB and MAPK activation.[Pubmed: 25637445] Int Immunopharmacol. 2015 Mar;25(1):83-7. Astragalin, a bioactive component isolated from Rosa agrestis, has been described to exhibit anti-inflammatory activity. The aim of this study was to investigate the anti-inflammatory effects and the underlying mechanisms of Astragalin on IL-1β-stimulated human osteoarthritis chondrocyte. |
Animal Research |
Astragalin suppresses inflammatory responses via down-regulation of NF-κB signaling pathway in lipopolysaccharide-induced mastitis in a murine model.[Pubmed: 23928506] Int Immunopharmacol. 2013 Oct;17(2):478-82. Mastitis is a prevalent and economic disease around the world and defined as infection and inflammation of the mammary gland. Astragalin, a bioactive component isolated from persimmon or Rosa agrestis, has been reported to have anti-inflammatory properties. |
Preparing Stock Solutions of Astragalin
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.2302 mL | 11.1508 mL | 22.3015 mL | 44.603 mL | 55.7538 mL |
5 mM | 0.446 mL | 2.2302 mL | 4.4603 mL | 8.9206 mL | 11.1508 mL |
10 mM | 0.223 mL | 1.1151 mL | 2.2302 mL | 4.4603 mL | 5.5754 mL |
50 mM | 0.0446 mL | 0.223 mL | 0.446 mL | 0.8921 mL | 1.1151 mL |
100 mM | 0.0223 mL | 0.1115 mL | 0.223 mL | 0.446 mL | 0.5575 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |