Fraxinol CAS NO.486-28-2

Min.Order: 10 Milligram
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Fraxinol
486-28-2
standard supplier in China

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ProName: Fraxinol
CasNo: 486-28-2
Molecular Formula: C11H10O5
Appearance: detailed see specifications
Application: analysis,activity test,Botanical Refer...
DeliveryTime: 1-3?working?days?after?confirming?the?...
PackAge: According to the clients requirement.
Port: China main port
ProductionCapacity: 1 Metric Ton/Day
Purity: ≥98%
Storage: Store at 2~8°C
Transportation: by air or by ocean shipping
LimitNum: 10 Milligram
Plant of Origin: Chinese herbal medicine
Testing Method: NMR/MS/HPLC
Product Ecification: 1mg-1kg
Heavy Metal: <10ppm
Voluntary Standards: company standard
Storage: Store in dry, dark and ventilated plac...
PackAge: Brown vial HDPE plastic bottle

Superiority

Chemical Properties of Fraxinol

Cas No.	486-28-2
PubChem ID	3047739	Appearance	White-yellowish powder
Formula	C₁₁H₁₀O₅	M.Wt	222.2
Type of Compound	Coumarins	Storage	Desiccate at -20°C
Synonyms	6-Hydroxy 5,7-dimethoxycoumarin
Solubility	Soluble in DMSO and methanol; slightly soluble in water
Chemical Name	6-hydroxy-5,7-dimethoxychromen-2-one
SMILES	COC1=C(C(=C2C=CC(=O)OC2=C1)OC)O
Standard InChIKey	PBPNOAHYDPHKFH-UHFFFAOYSA-N
Standard InChI	InChI=1S/C11H10O5/c1-14-8-5-7-6(3-4-9(12)16-7)11(15-2)10(8)13/h3-5,13H,1-2H3
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Fraxinol

The bark of Fraxinus chinensis Roxb

Biological Activity of Fraxinol

Description

Fraxinol is a natural product from Lobelia chinensis.

Protocol of Fraxinol

Structure Identification

Zhong Yao Cai. 2010 Nov;33(11):1721-4.

Studies on the chemical constituents from Lobelia chinensis.[Pubmed: 21434431]

To study the chemical constituents of the full plant of Lobelia chinensis.
METHODS AND RESULTS:
The compounds were isolated and purified using several column chromatographic methods. Their structures were elucidated based on their physicochemical properties and spectral data. Twelve compounds were isolated from L. chinensis. Their structures were elucidated as 6,7-dimethoxycoumarin (1), Fraxinol (2), 5-hydroxy-7-methoxycoumarin (3), tomentin (4), 3'-hydroxygenkwanin (5), apigenin (6), quercetin (7), luteolin (8), linarin (9), luteolin 3',4'-dimethylether-7-O-beta-D-glucoside (10), isoferulic acid (11), and ethyl ros-marinate (12), respectively.
CONCLUSIONS:
Compounds 1 -5 and 10 -12 are isolated from this plant for the first time.

Preparing Stock Solutions of Fraxinol

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.5005 mL	22.5023 mL	45.0045 mL	90.009 mL	112.5113 mL
5 mM	0.9001 mL	4.5005 mL	9.0009 mL	18.0018 mL	22.5023 mL
10 mM	0.45 mL	2.2502 mL	4.5005 mL	9.0009 mL	11.2511 mL
50 mM	0.09 mL	0.45 mL	0.9001 mL	1.8002 mL	2.2502 mL
100 mM	0.045 mL	0.225 mL	0.45 mL	0.9001 mL	1.1251 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on Fraxinol

New constituents of Artemisia monosperma Del.[Pubmed:18771012]

Pharmazie. 2008 Aug;63(8):611-4.

Phytochemical investigation of air-dried powdered roots of Artemisia monosperma growing in Egypt afforded two new compounds; 6-hydroxy-7,8-dimethoxycoumarin (I) and 5-acetyl-2-[1'-(hydroxymethyl)ethyl]-2,3-dihydrobenzo[b]furan (IV), in addition to the known compounds; 6-hydroxy-5,7-dimethoxycoumarin (Fraxinol) (II), 5-hydroxy-6,7-dimethoxycoumarin (tomentin) (III) and methyl-beta-D-fructofuranoside (V), obtained for the first time from the plant. Chemical structures of the isolated compounds were assigned based on different physical, chemical and spectroscopic techniques including UV, IR, MS, 1D- and 2D-NMR spectra. Furthermore, antimicrobial activity of different extracts of roots was carried out.

[Studies on the chemical constituents from Lobelia chinensis].[Pubmed:21434431]

Zhong Yao Cai. 2010 Nov;33(11):1721-4.

OBJECTIVE: To study the chemical constituents of the full plant of Lobelia chinensis. METHODS: The compounds were isolated and purified using several column chromatographic methods. Their structures were elucidated based on their physicochemical properties and spectral data. RESULTS: Twelve compounds were isolated from L. chinensis. Their structures were elucidated as 6,7-dimethoxycoumarin (1), Fraxinol (2), 5-hydroxy-7-methoxycoumarin (3), tomentin (4), 3'-hydroxygenkwanin (5), apigenin (6), quercetin (7), luteolin (8), linarin (9), luteolin 3',4'-dimethylether-7-O-beta-D-glucoside (10), isoferulic acid (11), and ethyl ros-marinate (12), respectively. CONCLUSION: Compounds 1 -5 and 10 -12 are isolated from this plant for the first time.

Description

Fraxinol is isolated from Lobelia chinensis.

Keywords:

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Details

Quantity:1mg-1kg
Function:analysis,activity test,Botanical Reference Materials,Standard materials
Hubei CuiRan Biotechnology Co., Ltd. is a high-tech enterprise that integrates research and development, production, and sales. It mainly engages in the production, customization, and production process development of high-purity Chinese medicine chemical components, Chinese medicine reference materials, high-quality extracts, natural product intermediates, and drug impurities.
CuiRan provides the following related services:
1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.