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Keywords
- Tyramine
- 51-67-2
- standard supplier in China
Quick Details
- ProName: Tyramine
- CasNo: 51-67-2
- Molecular Formula: C8H11NO
- Appearance: detailed see specifications
- Application: analysis,activity test,Botanical Refer...
- DeliveryTime: 1-3?working?days?after?confirming?the?...
- PackAge: According to the clients requirement.
- Port: China main port
- ProductionCapacity: 1 Metric Ton/Day
- Purity: ≥98%
- Storage: Store at 2~8°C
- Transportation: by air or by ocean shipping
- LimitNum: 10 Milligram
- Plant of Origin: Chinese herbal medicine
- Testing Method: NMR/MS/HPLC
- Product Ecification: 1mg-1kg
- Heavy Metal: <10ppm
- Voluntary Standards: company standard
- Storage: Brown vial HDPE plastic bottle
Superiority
Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.
Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library
1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries
General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.
Details
Chemical Properties of Tyramine
| Cas No. | 51-67-2 | ||
| PubChem ID | 5610 | Appearance | Powder |
| Formula | C8H11NO | M.Wt | 137.18 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 4-(2-aminoethyl)phenol | ||
| SMILES | C1=CC(=CC=C1CCN)O | ||
| Standard InChIKey | DZGWFCGJZKJUFP-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Source of Tyramine
The herbs of Uncaria rhynchophylla
Biological Activity of Tyramine
| Description | Tyramine is a major mutagen precursor in soy sauce, being convertible to a mutagen by nitrite; it is the biological precursor of octopamine, both compounds are independent neurotransmitters, acting through various G-protein coupled receptors, they are antagonistic modulators of behavior and metabolism. |
| Targets | G-protein coupled receptors |
| In vivo |
Tyramine Functions independently of octopamine in the Caenorhabditis elegans nervous system.[Reference: WebLink] Neuron, 2005 ,46 (2) :247-60. Octopamine biosynthesis requires tyrosine decarboxylase to convert tyrosine into Tyramine and Tyramine beta-hydroxylase to convert Tyramine into octopamine. |
Protocol of Tyramine
| Kinase Assay |
Tyramine and octopamine: antagonistic modulators of behavior and metabolism.[Pubmed: 12942511 ] Arch Insect Biochem Physiol. 2003 Sep;54(1):1-13. The phenolamines Tyramine and octopamine are decarboxylation products of the amino acid tyrosine. |
| Structure Identification |
Gan. 1984 Jan;75(1):1-3. Tyramine is a major mutagen precursor in soy sauce, being convertible to a mutagen by nitrite.[Pubmed: 6373470] Tyramine was identified as a new mutagen precursor in Japanese soy sauce, becoming mutagenic after treatment with nitrite under acidic conditions. The mutagenic compound was identified as 4-(2-aminoethyl)-6-diazo-2,4- cyclohexadienone , and its specific mutagenic activity was 112 revertants/micrograms towards Salmonella typhimurium TA100 without S9 mix. |
Preparing Stock Solutions of Tyramine
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 7.2897 mL | 36.4485 mL | 72.8969 mL | 145.7938 mL | 182.2423 mL |
| 5 mM | 1.4579 mL | 7.2897 mL | 14.5794 mL | 29.1588 mL | 36.4485 mL |
| 10 mM | 0.729 mL | 3.6448 mL | 7.2897 mL | 14.5794 mL | 18.2242 mL |
| 50 mM | 0.1458 mL | 0.729 mL | 1.4579 mL | 2.9159 mL | 3.6448 mL |
| 100 mM | 0.0729 mL | 0.3645 mL | 0.729 mL | 1.4579 mL | 1.8224 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
References on Tyramine
Tyramine and octopamine: antagonistic modulators of behavior and metabolism.[Pubmed:12942511]
Arch Insect Biochem Physiol. 2003 Sep;54(1):1-13.
The phenolamines Tyramine and octopamine are decarboxylation products of the amino acid tyrosine. Although Tyramine is the biological precursor of octopamine, both compounds are independent neurotransmitters, acting through various G-protein coupled receptors. Especially, octopamine modulates a plethora of behaviors, peripheral and sense organs. Both compounds are believed to be homologues of their vertebrate counterparts adrenaline and noradrenaline. They modulate behaviors and organs in a coordinated way, which allows the insects to respond to external stimuli with a fine tuned adequate response. As these two phenolamines are the only biogenic amines whose physiological significance is restricted to invertebrates, the attention of pharmacologists was focused on the corresponding receptors, which are still believed to represent promising targets for new insecticides. Recent progress made on all levels of octopamine/Tyramine research enabled us to better understand the molecular events underlying the control of complex behaviors.
Tyramine is a major mutagen precursor in soy sauce, being convertible to a mutagen by nitrite.[Pubmed:6373470]
Gan. 1984 Jan;75(1):1-3.
Tyramine was identified as a new mutagen precursor in Japanese soy sauce, becoming mutagenic after treatment with nitrite under acidic conditions. The mutagenic compound was identified as 4-(2-aminoethyl)-6-diazo-2,4- cyclohexadienone , and its specific mutagenic activity was 112 revertants/micrograms towards Salmonella typhimurium TA100 without S9 mix.
Description
Tyramine is an indirectly acting sympathomimetic amine that releases norepinephrine from presynaptic nerve terminals.
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