6-Methoxyluteolin CAS NO.520-11-6

Min.Order: 10 Milligram
Payment Terms: T/T
Available Specifications:

Product Details

Keywords

6-Methoxyluteolin
520-11-6
standard supplier in China

Quick Details

ProName: 6-Methoxyluteolin
CasNo: 520-11-6
Molecular Formula: C16H12O7=316.3
Appearance: detailed see specifications
Application: analysis,activity test,Botanical Refer...
DeliveryTime: 1-3?working?days?after?confirming?the?...
PackAge: According to the clients requirement.
Port: China main port
ProductionCapacity: 1 Metric Ton/Day
Purity: ≥98%
Storage: Store at 2~8°C
Transportation: by air or by ocean shipping
LimitNum: 10 Milligram
Plant of Origin: Chinese herbal medicine
Testing Method: NMR/MS/HPLC
Product Ecification: 1mg-1kg
Heavy Metal: <10ppm
Voluntary Standards: company standard
Storage: Store in dry, dark and ventilated plac...
PackAge: Brown vial HDPE plastic bottle

Superiority

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.

Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library

1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries

General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Details

Chemical Properties of 6-Methoxyluteolin

Cas No.	520-11-6
PubChem ID	5317284	Appearance	Yellow powder
Formula	C₁₆H₁₂O₇	M.Wt	316.3
Type of Compound	Flavonoids	Storage	Desiccate at -20°C
Synonyms	Eupafolin; 6-Methoxyluteolin; 3',4',5,7-Tetrahydroxy 6-methoxyflavone
Solubility	Soluble in methanol; slightly soluble in water
Chemical Name	2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one
SMILES	COC1=C(C=C2C(=C1O)C(=O)C=C(O2)C3=CC(=C(C=C3)O)O)O
Standard InChIKey	FHHSEFRSDKWJKJ-UHFFFAOYSA-N
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 6-Methoxyluteolin

1 Arnica sp. 2 Artemisia sp. 3 Baccharis sp. 4 Centaurea sp. 5 Cirsium sp. 6 Eupatorium sp. 7 Inula sp. 8 Lippia sp. 9 Salvia sp. 10 Scutellaria sp. 11 Tanacetum sp.

Biological Activity of 6-Methoxyluteolin

Description	1. 6-Methoxyluteolin has antioxidant activity. 2. 6-Methoxyluteolin is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.
Targets	Calcium Channel \| Histamine Receptor

Preparing Stock Solutions of 6-Methoxyluteolin

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1616 mL	15.8078 mL	31.6156 mL	63.2311 mL	79.0389 mL
5 mM	0.6323 mL	3.1616 mL	6.3231 mL	12.6462 mL	15.8078 mL
10 mM	0.3162 mL	1.5808 mL	3.1616 mL	6.3231 mL	7.9039 mL
50 mM	0.0632 mL	0.3162 mL	0.6323 mL	1.2646 mL	1.5808 mL
100 mM	0.0316 mL	0.1581 mL	0.3162 mL	0.6323 mL	0.7904 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on 6-Methoxyluteolin

6-Methoxyluteolin from Chrysanthemum zawadskii var. latilobum suppresses histamine release and calcium influx via down-regulation of FcepsilonRI alpha chain expression.[Pubmed:22561855]

J Microbiol Biotechnol. 2012 May;22(5):622-7.

Mast cells and basophils are important effector cells in immunoglobulin-E (IgE)-mediated allergic reactions. Using the human basophilic KU812F cells, we assessed the inhibitory effects of 6-Methoxyluteolin, isolated from Chrysanthemum zawadskii, in the FcepsilonRI-mediated allergic reaction. We determined that 6-Methoxyluteolin inhibited anti-FcepsilonRI alpha chain antibody (CRA-1)-induced histamine release, as well as elevation of intracellular calcium concentration [Ca2+]i in a dose-dependent manner. Moreover, the inhibitory effects of 6-Methoxyluteolin on the cell surface expression and the mRNA level of the FcepsilonRI alpha chain were determined by flow cytometric analysis and reverse transcription-polymerase chain reaction (RTPCR), respectively. Therefore, these results show that 6- methoxyluteolin is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcepsilonRI alpha chain.

Description

Nepetin (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Nepetin inhibits IL-6, IL-8 and MCP-1 secretion with IC50 values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells.

Keywords:

6-Methoxyluteolin,520-11-6,Eupafolin; 6-Methoxyluteolin; 3',4',5,7-Tetrahydroxy 6-methoxyflavone,Natural Products, buy 6-Methoxyluteolin , 6-Methoxyluteolin supplier , purchase 6-Methoxyluteolin , 6-Methoxyluteolin cost , 6-Methoxyluteolin manufacturer , order 6-Methoxyluteolin , high purity 6-Methoxyluteolin