γ-aminobutyricacid CAS NO.56-12-2

Min.Order: 10 Milligram
Payment Terms: T/T
Available Specifications:

Product Details

Keywords

56-12-2
γ-aminobutyricacid
High quality

Quick Details

ProName: γ-aminobutyricacid
CasNo: 56-12-2
Molecular Formula: C4H9NO2
Appearance: detailed see specifications
Application: analysis,activity test,Botanical Refer...
DeliveryTime: 1-3 working days after confirming
PackAge: According to the clients requirement.
Port: China main port
ProductionCapacity: 1 Metric Ton/Day
Purity: HPLC≥98%
Storage: Store at 2~8°C
Transportation: by air or by ocean shipping
LimitNum: 10 Milligram
Plant of Origin: Chinese herbal medicine
Testing Method: NMR/MS/HPLC
Product Ecification: 1mg-1kg
Heavy Metal: <10ppm
Voluntary Standards: Company standard

Superiority

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.

Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library

1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries

General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Details

Chemical Properties of 4-Aminobutanoic acid

Cas No.	56-12-2	SDF
PubChem ID	119	Appearance	White powder
Formula	C₄H₉NO₂	M.Wt	103.12
Type of Compound	Miscellaneous	Storage	Desiccate at -20°C
Synonyms	4-Aminobutanoic acid; 4-Aminobutyric acid; 3-Carboxypropylamine; GABA
Solubility	H2O : ≥ 50 mg/mL (484.87 mM) *"≥" means soluble, but saturation unknown.
Chemical Name	4-aminobutanoic acid
SMILES	C(CC(=O)O)CN
Standard InChIKey	BTCSSZJGUNDROE-UHFFFAOYSA-N
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of 4-Aminobutanoic acid

Description

Lower CSF 4-Aminobutanoic acid may explain increasing severity of psychic anxiety in major depression with increasing age, suggests treatments targeting the 4-Aminobutanoic acid ergic system should be evaluated in treatment-resistant anxious major depression and in older patients.

Targets

Sodium Channel | ATPase | Potassium Channel

In vivo

Anxiety in major depression and cerebrospinal fluid free 4-Aminobutanoic acid.[Pubmed: 24865448]

Depress Anxiety. 2014 Oct;31(10):814-21.

Low 4-Aminobutanoic acid (GABA) is implicated in both anxiety and depression pathophysiology. They are often comorbid, but most clinical studies have not examined these relationships separately.
METHODS AND RESULTS:
We investigated the relationship of cerebrospinal fluid (CSF) free 4-Aminobutanoic acid to the anxiety and depression components of a major depressive episode (MDE) and to monoamine systems. Psychic anxiety severity increased with age and correlated with lower CSF free 4-Aminobutanoic acid, controlling for age. CSF free 4-Aminobutanoic acid declined with age but was not related to depression severity. Other monoamine metabolites correlated positively with CSF 4-Aminobutanoic acid but not with psychic anxiety or depression severity. CSF free 4-Aminobutanoic acid was lower in MDD compared with bipolar disorder and healthy volunteers. 4-Aminobutanoic acid levels did not differ based on a suicide attempt history in mood disorders. Recent exposure to benzodiazepines, but not alcohol or past alcoholism, was associated with a statistical trend for more severe anxiety and lower CSF 4-Aminobutanoic acid.
CONCLUSIONS:
Lower CSF 4-Aminobutanoic acid may explain increasing severity of psychic anxiety in major depression with increasing age. This relationship is not seen with monoamine metabolites, suggesting treatments targeting the 4-Aminobutanoic acid ergic system should be evaluated in treatment-resistant anxious major depression and in older patients.

Protocol of 4-Aminobutanoic acid

Animal Research

Effect of 4-Aminobutanoic acid on digestive enzymes, absorption function, and immune function of intestinal mucosa in heat-stressed chicken.[Pubmed: 25085934]

Poult Sci. 2014 Oct;93(10):2490-500.

To explore the effect of dietary 4-Aminobutanoic acid (GABA) on digestive enzyme activity, absorption function and immune function of intestinal mucosa in heat-stressed Wenchang chicken were studied.
METHODS AND RESULTS:
One-day-old male Wenchang chickens were randomly divided into a control group (CK), heat stress group (HS), and 4-Aminobutanoic acid+HS group. The chickens from the 4-Aminobutanoic acid+HS group were administered with 0.2 mL of 4-Aminobutanoic acid solution daily. Chickens from HS and 4-Aminobutanoic acid+HS groups were subjected to heat stress treatment at 40 ± 0.5°C for 2 h during 1300 to 1500 h every day. Blood was drawn and 0.5 cm-long duodenum, jejunum, and ileum were collected from the chickens on d 3, 5, 7, 9, 12, and 15. Results showed that the activity of Ca²?-Mg²?-adenosine triphosphatase (ATPase), Na?-K?-ATPase, maltase, sucrase, and alkaline phosphatase, the contents of secretory IgA, glutathione, and d-xylose, and the number of lymphocytes in HS group were significantly lower than those in the CK group. Among them, some were rescued after the treatment of 4-Aminobutanoic acid as the time extension.

Preparing Stock Solutions of 4-Aminobutanoic acid

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	9.6974 mL	48.4872 mL	96.9744 mL	193.9488 mL	242.436 mL
5 mM	1.9395 mL	9.6974 mL	19.3949 mL	38.7898 mL	48.4872 mL
10 mM	0.9697 mL	4.8487 mL	9.6974 mL	19.3949 mL	24.2436 mL
50 mM	0.1939 mL	0.9697 mL	1.9395 mL	3.879 mL	4.8487 mL
100 mM	0.097 mL	0.4849 mL	0.9697 mL	1.9395 mL	2.4244 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.