Benzoic acid CAS NO.65-85-0

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General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
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Chemical Properties of Benzoic acid

Source of Benzoic acid

The herbs of Cerbera manghas L.

Biological Activity of Benzoic acid

Protocol of Benzoic acid

Preparing Stock Solutions of Benzoic acid

References on Benzoic acid

Effects of benzoic Acid and thymol on growth performance and gut characteristics of weaned piglets.[Pubmed:25925060]

Asian-Australas J Anim Sci. 2015 Jun;28(6):827-39.

A total of 144 weaned crossed pigs were used in a 42-d trial to explore the effects of different concentrations/combinations of Benzoic acid and thymol on growth performance and gut characteristics in weaned pigs. Pigs were randomly allotted to 4 dietary treatments: i) control (C), basal diet, ii) C+1,000 mg/kg Benzoic acid+100 mg/kg thymol (BT1), iii) C+1,000 mg/kg Benzoic acid+200 mg/kg thymol (BT2) and, iv) C+2,000 mg/kg Benzoic acid+100 mg/kg thymol (BT3). Relative to the control, pigs fed diet BT3 had lower diarrhoea score during the overall period (p<0.10) and improved feed to gain ratio between days 1 to 14 (p<0.05), which was accompanied by improved apparent total tract digestibility of ether extract, Ca and crude ash (p<0.05), and larger lipase, lactase and sucrose activities in the jejunum (p<0.05) at d 14 and d 42. Similarly, relative to the control, pigs fed diet BT3 had higher counts for Lactobacillus spp in digesta of ileum at d 14 (p<0.05), and pigs fed diets BT1, BT2, or BT3 also had higher counts of Bacillus spp in digesta of caecum at d 14 (p<0.05), and lower concentration of ammonia nitrogen in digesta of caecum at d 14 and d 42 (p<0.05). Finally, pigs fed diet BT3 had higher concentration of butyric acid in digesta of caecum at d 42 (p<0.05), and a larger villus height:crypt depth ratio in jejunum and ileum at d 14 (p<0.05) than pigs fed the control diet. In conclusion, piglets fed diet supplementation with different concentrations/combinations of Benzoic acid and thymol could improve feed efficiency and diarrhoea, and improve gut microfloral composition. The combination of 2,000 mg/kg Benzoic acid+100 mg/kg thymol produced better effects than other treatments in most measurements.

Steric hindrance of 2,6-disubstituted benzoic acid derivatives on the uptake via monocarboxylic acid transporters from the apical membranes of Caco-2 cells.[Pubmed:24861932]

Pestic Biochem Physiol. 2014 May;111:38-42.

Benzoic acid is a typical substrate for monocarboxylic acid transporters (MCTs), and easily taken up from the apical membranes of Caco-2 cells by MCTs. However, some Benzoic acid derivatives were sparingly taken up by Caco-2 cells. To elucidate the mechanism of lower uptake of the derivatives, we investigated the effect of substitution of benzene ring on the uptake by MCTs using Caco-2 cells. Among the Benzoic acid derivatives tested, the uptake of 2,6-disubstituted Benzoic acids was markedly lower than that of other Benzoic acids. Co-incubation of the 2,6-disubstituted derivatives with Benzoic acid did not decrease the uptake of Benzoic acid, while co-incubation with other derivatives significantly decreased the uptake of Benzoic acid. Kinetic analyses elucidated that the uptake of 2,6-dichloroBenzoic acid and 2,3,6-trichloroBenzoic acid did not involve the carrier-mediated process. The 2,6-disubstitution of Benzoic acid may prevent the access of carboxylic acid group to MCTs expressed on the apical membranes of Caco-2 cells.

Description

Benzoic acid is an aromatic alcohol existing naturally in many plants and is a common additive to food, drinks, cosmetics and other products. It acts as preservatives through inhibiting both bacteria and fungi.

Keywords:

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