Sodium Danshensu CAS NO.67920-52-9

Min.Order: 10 Milligram
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Sodium Danshensu
67920-52-9
standard supplier in China

Quick Details

ProName: Sodium Danshensu
CasNo: 67920-52-9
Molecular Formula: C9H9O5Na=220.2
Appearance: detailed see specifications
Application: analysis,activity test,Botanical Refer...
DeliveryTime: 1-3?working?days?after?confirming?the?...
PackAge: According to the clients requirement.
Port: China main port
ProductionCapacity: 1 Metric Ton/Day
Purity: ≥98%
Storage: Store at 2~8°C
Transportation: by air or by ocean shipping
LimitNum: 10 Milligram
Plant of Origin: Chinese herbal medicine
Testing Method: NMR/MS/HPLC
Product Ecification: 1mg-1kg
Heavy Metal: <10ppm
Voluntary Standards: company standard
Storage: Store in dry, dark and ventilated plac...
PackAge: Brown vial HDPE plastic bottle

Superiority

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.

Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library

1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries

General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Details

Chemical Properties of Sodium Danshensu

Cas No.	67920-52-9	SDF
PubChem ID	23711819	Appearance	White-beige powder
Formula	C₉H₉O₅Na	M.Wt	220.2
Type of Compound	Phenylpropanoids	Storage	Desiccate at -20°C
Synonyms	Sodium Danshensu; (±)-DanShenSu sodium sal
Solubility	H2O : 100 mg/mL (454.24 mM; Need ultrasonic) DMSO : 100 mg/mL (454.24 mM; Need ultrasonic)
Chemical Name	sodium;3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate
SMILES	C1=CC(=C(C=C1CC(C(=O)[O-])O)O)O.[Na+]
Standard InChIKey	ZMMKVDBZTXUHFO-UHFFFAOYSA-M
Standard InChI	InChI=1S/C9H10O5.Na/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14;/h1-3,8,10-12H,4H2,(H,13,14);/q;+1/p-1
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Sodium Danshensu

The root of Salvia miltiorrhiza Bge.

Biological Activity of Sodium Danshensu

Description	Sodium danshensu (SDSS), the sodium salt of danshensu (DSS), has the neuroprotective effect against cerebral I/R injury, and the potential mechanism might to inhibition of apoptosis through activating the PI3K/Akt signal pathway. SDSS has a protective effect against the genotoxicity of cigarette smoke，it shows a biphasic effects on vessel tension, while low dosage of sodium danshensu produces small contraction possibly through transient enhancement of Ca(2+) influx, high dosage produces significant vasodilation mainly through promoting the opening of non-selective K(+) channels and small-conductance calcium-sensitive K(+) channels in the vascular smooth muscle cells.
Targets	Calcium Channel \| Potassium Channel \| Akt \| GSK-3 \| Bcl-2/Bax \| PI3K
In vitro	Protection of flavonoid components baicalein,quercetin,or sodium danshensu on cytotoxicity and cellular DNA damage induced by cigarette smoke[Reference: WebLink] Drugs & Clinic, 2014, 29(1):21-6. To evaluate the protective effect of flavonoid components baicalein, quercetin or Sodium Danshensu on cytotoxicity and cellular DNA damage induced by cigarette smoke. Methods Two kinds of eukaryotic cells B-16 cells and oral buccal mucosal cells in liquid were attacked by the mainstream smoke produced via on-line cigarette smoking according to FTC with or without baicalein, quercetin or Sodium Danshensu. The cytotoxicity and cellular DNA damage were respectively assessed by MTT method and single cell gel electrophoresis. Results The cytotoxicity of B-16 cells and DNA damage of two kinds of cells induced by on-line cigarette smoking were obvious. A positive relationship was observed between the exposure time in smoke and the tail moment and olive tail moment of comet cells. Baicalein, quercetin, or Sodium Danshensu(1 mmol/L) could relieve the cytotoxicity by about 50% and decrease the DNA damage by more than 60%. Conclusion There is a positive relationship between the exposure of cells in smoke and the cellular DNA damage, and the flavonoid components baicalein, quercetin, or Sodium Danshensu have a protective effect against the genotoxicity of cigarette smoke.
In vivo	Biphasic effects of sodium danshensu on vessel function in isolated rat aorta.[Pubmed: 20228827] Acta Pharmacol Sin. 2010 Apr;31(4):421-8. To investigate the effects of Sodium Danshensu on vessel function in isolated rat aortic ring. METHODS AND RESULTS: Thoracic aortae from normal rats were isolated and equilibrated in organ bath with Krebs-Henseleit buffer and ring tension was recorded. Effects of Sodium Danshensu on basal tonus of the vessel and its effects on vessel contraction and relaxation with or without endothelium were observed. In thoracic arteries under basal tonus, Sodium Danshensu (0.3-3 g/L) produced a dose-dependent transient contraction. In phenylephrine-precontracted thoracic arteries with or without endothelium, low concentration (0.1-0.3 g/L) of Sodium Danshensu produced a weak contraction, while high concentrations (1-3 g/L) produced a pronounced vasodilator after a transient vasocontraction. Pre-incubation with Sodium Danshensu could inhibit vessel contraction induced by phenylephrine and potassium chloride in a concentration-dependent way. Sodium Danshensu inhibited phenylephrine- and CaCl(2)-induced vasoconstriction in Ca(2+)-free medium. Pre-incubation with tetraethylammonium, a non-selective K(+) channel blocker, and apamin, a small-conductance calcium-activated K(+) channel blocker partially antagonized the relaxation response induced by Sodium Danshensu. However, iberiotoxin (big-conductance calcium-sensitive K(+) channel blocker), barium chloride (inward rectifier K(+) channel blocker), and glibencalmide (ATP-sensitive K(+) channel blocker) had no influence on the vasodilation effect of Sodium Danshensu. CONCLUSIONS: Sodium Danshensu showed a biphasic effects on vessel tension. While low dosage of Sodium Danshensu produced small contraction possibly through transient enhancement of Ca(2+) influx, high dosage produced significant vasodilation mainly through promoting the opening of non-selective K(+) channels and small-conductance calcium-sensitive K(+) channels in the vascular smooth muscle cells.

Protocol of Sodium Danshensu

Animal Research

Neuroprotective effect and underlying mechanism of sodium danshensu [3-(3,4-dihydroxyphenyl) lactic acid from Radix and Rhizoma Salviae miltiorrhizae = Danshen] against cerebral ischemia and reperfusion injury in rats.[Pubmed: 25765834 ]

Phytomedicine. 2015 Feb 15;22(2):283-9.

Sodium Danshensu (SDSS), the sodium salt of danshensu (DSS), has the same pharmacological effects as DSS.
METHODS AND RESULTS:
In the present study, we aimed to investigate the neuroprotective effect and possible mechanism of SDSS against cerebral ischemic/reperfusion injury. Sprague-Dawley rats were randomly divided into four groups: sham, control, 30 mg/kg and 60 mg/kg SDSS. Cerebral ischemia was induced by 2 h of middle cerebral artery occlusion (MCAO). Neurological functional deficits were evaluated according to the modified neurological severity score (mNSS); cerebral infarct volume and histological damage were measured by TTC or H-E staining. In addition, the number of apoptotic cells and caspase 3/7 activity were assessed by TUNEL or Caspase-Glo assay. And the expression of apoptosis-regulatory proteins and the PI3K/Akt pathway were investigated by western blotting. Our results showed that treatment with SDSS for 5 days after MCAO remarkably improved neurologic deficits and survival rate, reduced infarct volume and the number of dead neurons. SDSS also decreased the number of apoptotic cells, regulated the expression of Bcl-2 and Bax, and increased the ratio of Bcl-2/Bax. Further study revealed that treatment with SDSS also increased the level of p-Akt and p-GSK-3β.
CONCLUSIONS:
Taken together, our results suggest that SDSS has the neuroprotective effect against cerebral I/R injury, and the potential mechanism might to inhibition of apoptosis through activating the PI3K/Akt signal pathway.

Preparing Stock Solutions of Sodium Danshensu

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.5413 mL	22.7066 mL	45.4133 mL	90.8265 mL	113.5332 mL
5 mM	0.9083 mL	4.5413 mL	9.0827 mL	18.1653 mL	22.7066 mL
10 mM	0.4541 mL	2.2707 mL	4.5413 mL	9.0827 mL	11.3533 mL
50 mM	0.0908 mL	0.4541 mL	0.9083 mL	1.8165 mL	2.2707 mL
100 mM	0.0454 mL	0.2271 mL	0.4541 mL	0.9083 mL	1.1353 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.