Laetanine CAS NO.72361-67-2

Min.Order: 10 Milligram
Payment Terms: T/T
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Laetanine
72361-67-2
standard supplier in China

Quick Details

ProName: Laetanine
CasNo: 72361-67-2
Molecular Formula: C18H19NO4= 313.35
Appearance: detailed see specifications
Application: analysis,activity test,Botanical Refer...
DeliveryTime: 1-3?working?days?after?confirming?the?...
PackAge: According to the clients requirement.
Port: China main port
ProductionCapacity: 1 Metric Ton/Day
Purity: ≥98%
Storage: Store at 2~8°C
Transportation: by air or by ocean shipping
LimitNum: 10 Milligram
Plant of Origin: Chinese herbal medicine
Testing Method: NMR/MS/HPLC
Product Ecification: 1mg-1kg
Heavy Metal: <10ppm
Voluntary Standards: company standard
Storage: Store in dry, dark and ventilated plac...
PackAge: Brown vial HDPE plastic bottle

Superiority

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.

Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library

1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries

General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Details

Chemical Properties of Laetanine

Cas No.	72361-67-2
PubChem ID	129371873	Appearance	Powder
Formula	C₁₈H₁₉NO₄	M.Wt	313.35
Type of Compound	Alkaloids	Storage	Desiccate at -20°C
Solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name	(6aS)-1,9-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,10-diol
SMILES	COC1=C(C=C2C(=C1)CC3C4=C2C(=C(C=C4CCN3)O)OC)O
Standard InChIKey	URQAEFLEDPPPFX-LBPRGKRZSA-N
Standard InChI	InChI=1S/C18H19NO4/c1-22-15-7-10-5-12-16-9(3-4-19-12)6-14(21)18(23-2)17(16)11(10)8-13(15)20/h6-8,12,19-21H,3-5H2,1-2H3/t12-/m0/s1
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Laetanine

The herbs of Litsea laeta

Protocol of Laetanine

Structure Identification

Masters thesis,2009, University of Malaya.

Alkaloids isolated from litsea petiolata and phoebe tavoyana (Lauraceae).[Reference: WebLink]

A study on the alkaloidal composition of two Malaysian plants from the family of Lauraceae i.e Litsea petiolata Hk.F and Phoebe tavoyana (Meissn.) Hk.F., has been carried out.
METHODS AND RESULTS:
The alkaloids were extracted with dichloromethane, whereas the isolation of the alkaloids was achieved by various chromatographic techniques such as column chromatography and preparative thin layer chromatography. A total of 14 compounds were isolated of which two are new alkaloids. The structural elucidations were carried out via spectroscopic methods; notably 1D and 2D NMR (COSY, HMQC, HMBC, NOE-DIFF), MS, IR, UV and comparison with the published data. Investigation of the alkaloidal content from the bark of Litsea petiolata afforded five alkaloids. Compounds isolated are two indole alkaloids (Î2-carboline) namely Harman or aribine 52, norharman 53, along with the three known isoquinoline alkaloids which normally occur in Lauraceae plant; Benzylisoquinolines: reticuline 31, aporphine: isoboldine 61; and one simple isoquinoline: thalifoline 100. Î2-carboline alkaloid: Harman and norharman type were isolated for the first time in the genus of Litsea.
CONCLUSIONS:
Isolation and purification of alkaloids from the bark of Phoebe tavoyana afforded 9 alkaloids of which 2 are new compounds: (+)-tavoyanine 101 and (-)-tavoyanine 102 along with four known aporphines; norboldine 77, Laetanine 73, roemerine 84, boldine 74 and one morphinandienone, sebiferine 103.

Preparing Stock Solutions of Laetanine

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1913 mL	15.9566 mL	31.9132 mL	63.8264 mL	79.783 mL
5 mM	0.6383 mL	3.1913 mL	6.3826 mL	12.7653 mL	15.9566 mL
10 mM	0.3191 mL	1.5957 mL	3.1913 mL	6.3826 mL	7.9783 mL
50 mM	0.0638 mL	0.3191 mL	0.6383 mL	1.2765 mL	1.5957 mL
100 mM	0.0319 mL	0.1596 mL	0.3191 mL	0.6383 mL	0.7978 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on Laetanine

Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana.[Pubmed:30897964]

J Asian Nat Prod Res. 2019 Mar 21:1-9.

One new aporphine named tavoyanine A (1), along with four known aporphines Laetanine (2), roemerine (3), laurolitsine (4), and boldine (5), and one morphinandienone type sebiferine (6) were isolated from the leaves of Phoebe tavoyana (Meissn.) Hook f. (Lauraceae). The isolation was achieved by chromatographic techniques, and the structural elucidation was performed via spectral methods. This paper also reports the antiplasmodial activity of roemerine (3), laurolitsine (4), boldine (5), and sebiferine (6). The results showed that 3-6 have a potent inhibitory activity against the growth of Plasmodium falciparum 3D7 clone, with IC50 values of 0.89, 1.49, 1.65, and 2.76 microg/ml, respectively.

Description

Laetanine, a noraporphine alkaloid from Litsea laeta, exhibits antiplasmodial activity.

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