Rosavin High quality/Best price/In stock CAS NO.84954-92-7

Min.Order: 10 Milligram
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Quick Details

ProName: Rosavin
CasNo: 84954-92-7
Molecular Formula: C20H28O10=428.43
Appearance: detailed see specifications
Application: analysis,activity test,Botanical Refer...
DeliveryTime: 1-3?working?days?after?confirming?the?...
PackAge: According to the clients requirement.
Port: China main port
ProductionCapacity: 1 Metric Ton/Day
Purity: ≥98%
Storage: Store at 2~8°C
Transportation: by air or by ocean shipping
LimitNum: 10 Milligram
Plant of Origin: Chinese herbal medicine
Testing Method: NMR/MS/HPLC
Product Ecification: 1mg-1kg
Heavy Metal: <10ppm
Voluntary Standards: company standard
Storage: Store in dry, dark and ventilated plac...
PackAge: Brown vial HDPE plastic bottle

Superiority

Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine，Traditional Chinese Medicine), Natural Active Pharmaceutical Ingredients worldwide. From small quantities for R&D or reference standard, to large quantities for customizing or manufacturing, Biopurify emphasizes on consistent and reliable services for his customers.
With excellent quality products and good service, we have clients from more than dozens countries and regions, and we pride ourselves in providing our customers with a total satisfaction experiences.
We are doing our best to be your reliable partner for high quality Phytochemicals and Reference Standards from china.

Our main services:
A. Supply active ingredients and reference standards ofTraditional Chinese Medicine, from mgs to kgs scale.
B. Custom extraction and purification, target Herb Active Ingredients
C. Custom synthesis and semi-synthesis for Natural Active Ingredients
D. CR, CM and PD services from lab scale, pilot scale to commercial scale(GMP is also available)
E.Traditional Chinese Medicine compounds library

1.Provide traditional Chinese medicine reference materials and natural active ingredients;
2.More than 2200 compounds are available for selection, continuously building high-quality natural product libraries for drug research and development;
3.Provide various screening libraries and more inhibitor products;
4.Provide separation and structural determination of natural products;
5.Laboratory scale pilot to commercial scale collaborative research and process development services.More than 180 experiences in phytochemistry (still increasing)
Each product has passed very strict testing (NMR/MS/HPLC)
Agents from many countries

General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging：1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition：Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Details

Chemical Properties of Rosavin

Cas No.	84954-92-7	SDF
PubChem ID	6440755	Appearance	White-beige powder
Formula	C₂₀H₂₈O₁₀	M.Wt	428.43
Type of Compound	Phenylpropanoids	Storage	Desiccate at -20°C
Synonyms	Rosavidin
Solubility	Soluble in ethanol and water
Chemical Name	(2S,3R,4S,5S,6R)-2-[(E)-3-phenylprop-2-enoxy]-6-[[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxymethyl]oxane-3,4,5-triol
SMILES	C1C(C(C(C(O1)OCC2C(C(C(C(O2)OCC=CC3=CC=CC=C3)O)O)O)O)O)O
Standard InChIKey	RINHYCZCUGCZAJ-UHAHJPEESA-N
Standard InChI	InChI=1S/C20H28O10/c21-12-9-28-19(17(25)14(12)22)29-10-13-15(23)16(24)18(26)20(30-13)27-8-4-7-11-5-2-1-3-6-11/h1-7,12-26H,8-10H2/b7-4+/t12-,13+,14-,15+,16-,17+,18+,19-,20-/m0/s1
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging	1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment.
Shipping Condition	Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Rosavin

The herb of Rhodiola rosea L.

Biological Activity of Rosavin

Description

Rosavin possesses anti-fatigue, antidepressant and anxiolytic activities, it decreased neovascular reaction on cutaneous angiogenesis induced in mice after grafting of syngeneic tumor cells.

In vivo

Anti-fatigue effects of rosavin extracted from Rhodiola rosea L.[Reference: WebLink]

Science & Technology of Food Industry, 2013, 34(6):357-9.

To study the anti-fatigue effects of Rosavin extracted from Rhodiola rosea L. in mice.
METHODS AND RESULTS:
The mice were randomly divided into five groups including the control group administered with physiological saline,three Rosavin groups administered with doses of 60,180,360mg/kg mb Rosavin and salidroside group(180mg/kg mb) for 30 consecutive days,respectively. And the level of muscle lactate,liver and muscle glycogen,serum urea nitrogen and the exhaustive swimming time were determined after swimming test. Results:Compared with control group,different doses of Rosavin significantly extended the swimming time(p0.05) and increased the contents of liver(p0.05)and muscle glycogen,while reducing that of lactate in muscle significantly(p0.05). Salidroside was slightly better than Rosavin in the anti-fatigue effects of the same dose. But there was no significant difference in Rosavin and salidroside(p0.05).
CONCLUSIONS:
Rosavin had anti-fatigue effect on mice.

Protocol of Rosavin

Animal Research

The influence of Rhodiola rosea extracts and rosavin on cutaneous angiogenesis induced in mice after grafting of syngeneic tumor cells[Reference: WebLink]

Central-European Journal of Immunology, 2008, 33(3):102-7.

Anticancer research on the plant species Rhodiola rosea L. (Crassulaceae) has begun in animal models in 1987. In combination with cyclophosphamide, R. rosea extract enhanced the anti-tumor and anti-metastatic effects of drug treatment and reduced drug-induced toxicity. Combined with Adriamycin®, it improved inhibition of tumor dissemination and prevented liver toxicity.
METHODS AND RESULTS:
The aim of the present work was to study the effect of Rosavin and aqueous and 50% hydroalcoholic extracts of R. rosea roots and rhizomes on neovascular reaction induced in the skin of Balb/c mice after grafting of L-1 sarcoma cells. Mice were treated per os with 50, 100, 200 and 400 μg of extracts, or were fed Rosavin in daily doses 2, 4 and 8 μg. After 72 hours mice were sacrificed with lethal dose of Morbital. All newly formed blood vessels were identified and counted in dissection microscope. Both extracts in 100-400 μg daily doses and Rosavin in the highest dose highly significantly decreased neovascular reaction.

Structure Identification

Biotechnol Lett. 2014 Mar;36(3):649-56.

Biotransformation of cinnamyl alcohol to rosavins by non-transformed wild type and hairy root cultures of Rhodiola kirilowii.[Pubmed: 24190481]

Non-transformed wild type (NTWT) and hairy root cultures of Rhodiola kirilowii were grown in medium supplemented with 2.5 mM cinnamyl alcohol as a precursor and/or sucrose (1 %) on the day of inoculation or on the 14th day of culture. Rosarin, Rosavin, and rosin were produced by NTWT root culture but only rosarin and Rosavin by hairy roots. Approximately 80 and 95 % of the glycosides were released into the medium for NTWT and hairy root cultures, respectively. The highest Rosavin yield, 505 ± 106 mg/l, was in hairy root culture when cinnamyl alcohol was applied on the day of inoculation with the addition of sucrose on the 14th day of culture. For rosin production, supplementation with cinnamyl alcohol alone on day 14 was more favourable with the highest amount 74 ± 10 mg/l in NTWT root culture. Only traces of rosarin were detected.

Preparing Stock Solutions of Rosavin

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3341 mL	11.6705 mL	23.341 mL	46.6821 mL	58.3526 mL
5 mM	0.4668 mL	2.3341 mL	4.6682 mL	9.3364 mL	11.6705 mL
10 mM	0.2334 mL	1.1671 mL	2.3341 mL	4.6682 mL	5.8353 mL
50 mM	0.0467 mL	0.2334 mL	0.4668 mL	0.9336 mL	1.1671 mL
100 mM	0.0233 mL	0.1167 mL	0.2334 mL	0.4668 mL	0.5835 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.